The cross sections for nuclear reactions natEr(α,x) were measured in the energy range 60 → 10 MeV using the stacked-foil technique. The experiments were carried out in a wider energy range in comparison with previous works. The results are consistent with other studies and modeling using TENDL-2019. The 167Tm yield was 5.4 MBq/μAh in the range 60 → 30 MeV, and the main long-lived impurity is 168Tm (0.78% in terms of activity). The 165Tm yield is 4.6 MBq/μAh (60 → 40 MeV). 169Yb is formed with a yield of 1.0 MBq/μAh in the energy range 60 → 20 MeV.

This paper describes development of (169)Yb-seeds by encapsulating 0.6-0.65 mm (ϕ) sized (169)Yb2O3 microspheres in titanium capsules. Microspheres synthesized by a sol-gel route were characterized by XRD, SEM/EDS and ICP-AES. Optimization of neutron irradiation was accomplished and (169)Yb-seeds up to 74 MBq of (169)Yb could be produced from natural Yb2O3 microspheres, which have the potential for use in prostate brachytherapy. A protocol to prepare (169)Yb-brachytherapy sources (2.96-3.7 TBq of (169)Yb) with the use of enriched targets was also formulated.

BACKGROUND: The aim of the present study was to develop and demonstrate a viable method for the reactor production of (169)Er with acceptable specific activity using moderate flux reactor and its purification from (169)Yb following electrochemical pathway based on mercury-pool cathode to avail (169)Er in radionuclidically pure form essential for its therapeutic use.
METHODS: Erbium-169 was produced in reactor by neutron bombardment of isotopically enriched (98.2% in (168)Er) erbium target at a thermal neutron flux of ~8×10(13) n.cm(-2).s(-1) for 21 d. A thorough optimization of irradiation parameters including neutron flux, irradiation time and target cooling time was carried out. The influence of different experimental parameters for the quantitative removal (169)Yb from (169)Er was investigated, optimized and based on the results; a two-cycle electrochemical separation procedure was adopted. The suitablility of purified (169)Er for application in radiation synovectomy and bone pain palliation was ascertained by carrying out radiolabeling studies with hydroxypaptite (HA) particles and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminomethylene phosphonic acid (DOTMP), respectively.
RESULTS: Thermal neutron irradiation of 10mg of isotopically enriched (98.2% in (168)Er) erbium target at a flux of ~8×10(13) n.cm(-2).s(-1) for 21 d followed by a two-step electrochemical separation of (169)Yb impurity yielded ~3.7GBq (100mCi) of (169)Er with a specific activity of ~370MBq/mg (10mCi/mg) and radionuclidic purity of >99.99%. The reliability of this approach was amply demonstrated by performing several production batches, where the performance of each batch remained consistent. The utility of the purified (169)Er was demonstrated in the radiolabeling studies with HA particles and DOTMP, wherein both the radiolabeled products were obtained with high radiolabeling yield (>99%).
CONCLUSIONS: A viable strategy for the batch production and purification of (169)Er, suitable for therapeutic applications, has been developed and demonstrated.