背景:我们旨在描述中国呼伦贝尔地区NAFLD患者血清25-羟维生素D浓度与循环脂质浓度之间的关系。
方法:一百五十六名患者,2021年1月至2023年3月间在内蒙古民族大学第二临床学院体检科确诊为NAFLD组,同期招募160名健康人作为对照组。血清25(OH)VitD,TBIL,TG,TC,LDL-C,HDL-C,AST,ALT,GGT,测量参与者的FPG活动,并进行肝脏超声检查。
结果:NAFLD组的BMI高于对照组(p<0.05)。NAFLD组血清25(OH)VitD3(p<0.05)和HDL-C浓度均低于正常对照组。然而,AST(p<0.05),ALT(p<0.05),和GGT(p<0.05)活性,和血清TG(p<0.05),TC(p<0.05),LDL-C(p<0.05),NAFLD组空腹血糖浓度高于正常对照组(p<0.05)。NAFLD组血清25(OH)VitD3浓度与BMI呈显著负相关(r=-0.302,p<0.01),TG(r=-0.221,p<0.05),空腹血糖(r=-0.236,p<0.05)。BMI,TG,维生素D缺乏参与者的空腹血糖高于维生素D水平充足或不足的参与者(p<0.05)。最后,维生素D缺乏的参与者的BMI高于维生素D充足的参与者(p<0.05).
结论:在中国呼伦贝尔地区的人群中,25(OH)VitD缺乏比其他地方更常见。此外,维生素D状态与NAFLD显著相关;随着血清维生素D浓度降低,NAFLD患者表现出更大的血脂异常和高血糖,以及更高的BMI.
BACKGROUND: We aimed to characterize the relationship between the serum 25-hydroxyvitamin D concentration and the circulating lipid concentrations of patients with NAFLD in the Hulunbuir region of China.
METHODS: One hundred fifty-six patients, who were diagnosed with NAFLD in the Physical Examination Department of the Second Clinical College of Inner Mongolia University for the Nationalities between January 2021 and March 2023, were recruited as NAFLD group, and 160 healthy people were recruited as a control group during the same period. The serum 25(OH)VitD, TBIL, TG, TC, LDL-C, HDL-C, AST, ALT, GGT, and FPG activities of the participants were measured, and hepatic ultrasonography was performed.
RESULTS: The BMI of the NAFLD group was higher than of the control group (p < 0.05). The serum 25(OH)VitD3 (p < 0.05) and the HDL-C concentrations of the NAFLD group were lower than those of the normal control group. However, the AST (p < 0.05), ALT (p < 0.05), and GGT (p < 0.05) activities, and the serum TG (p < 0.05), TC (p < 0.05), LDL-C (p < 0.05), and the fasting glucose (p < 0.05) concentrations of the NAFLD group were higher than those of the normal control group. The serum 25(OH)VitD3 concentrations of the NAFLD group significantly cor-related negatively with BMI (r = -0.302, p < 0.01), TG (r = -0.221, p < 0.05), and fasting glucose (r = -0.236, p < 0.05). The BMI, TG, and fasting glucose of vitamin D-deficient participants were higher than of the participants with adequate or insufficient levels of vitamin D (p < 0.05). Finally, the BMI of vitamin D-deficient participants was higher than of those with an adequate vitamin D status (p < 0.05).
CONCLUSIONS: A deficiency of 25(OH)VitD is more common in people from the Hulunbuir region of China than elsewhere. In addition, the vitamin D status is significantly associated with NAFLD; as the serum vitamin D concentration decreases, patients with NAFLD show greater dyslipidemia and hyperglycemia and a higher BMI.