背景:基线甘油三酯葡萄糖指数(TyG指数)与非传染性疾病之间的关联,主要在亚洲人群中,已被报道。在目前的研究中,我们的目标是评估指数年之间的关联,平均,和TyG指数的访视变异性(VVV)与2型糖尿病(T2DM),高血压,心血管疾病(CVD),以及伊朗人口的全因死亡率。
方法:研究人群包括5220名受试者(2195名男性),年龄≥30岁。TyG指数计算为Ln(空腹甘油三酯(mg/dL)X空腹血浆葡萄糖(mg/dL)/2)。在2002年至2011年(指数年)的暴露期间,得出了TyG指数和VVV的平均值(通过标准偏差(SD)和独立于平均值的变异性进行评估)。使用多变量Cox比例风险回归模型来估计不同事件健康结果的TyG指数的风险比(HR)和95%置信区间(CI)。
结果:在指标年后的6年多的随访中,290、560、361和280个T2DM事件,高血压,CVD,和全因死亡率发生。指数年TyG指数值的1-SD增加与T2DM事件独立相关[HR(95%CI)2.50(2.13-2.93)];TyG指数平均值的相应值为2.37(2.03-2.76),1.12(0.99-1.26,pvalue=0.05),1.18(1.01-1.36),和1.29(1.08-1.53)的T2DM,高血压,CVD,和全因死亡率,分别。与第一个三分地相比,TyG指数的VVV三角3与高血压事件独立相关[1.33(1.07-1.64),Ptrend<0.01]。同样,TyG指数的VVV增加1-SD与高血压事件的11%超额风险相关[1.11(1.02-1.21)].然而,未发现TyG指数的VVV与其他结局之间存在关联.此外,TyG指数-年和平均值对女性心血管事件的影响更为显著(P=0.05).
结论:尽管在指数年较高的TyG指数及其VVV仅与T2DM和高血压相关,分别,其平均值能够捕获所有健康结局的风险.
BACKGROUND: The association between baseline triglyceride glucose index (TyG index) and incident non-communicable diseases, mainly in Asian populations, has been reported. In the current study, we aimed to evaluate the association between index-year, average, and visit-to-visit variability (VVV) of the TyG index with incident type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease (CVD), and all-cause mortality among the Iranian population.
METHODS: The study population included 5220 participants (2195 men) aged ≥ 30 years. TyG index was calculated as Ln (fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2). Average values of the TyG index and also VVV (assessed by the standard deviation (SD) and variability independent of mean) were derived during the exposure period from 2002 to 2011 (index-year). Multivariable Cox proportional hazards regression models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of the TyG index for incident different health outcomes.
RESULTS: During more than 6 years of follow-up after the index year, 290, 560, 361, and 280 events of T2DM, hypertension, CVD, and all-cause mortality occurred. 1-SD increase in the TyG index values at the index-year was independently associated with the incident T2DM [HR (95% CI) 2.50 (2.13-2.93)]; the corresponding values for the average of TyG index were 2.37 (2.03-2.76), 1.12 (0.99-1.26, pvalue = 0.05), 1.18 (1.01-1.36), and 1.29 (1.08-1.53) for incident T2DM, hypertension, CVD, and all-cause mortality, respectively. Compared to the first tertile, tertile 3 of VVV of the TyG index was independently associated with incident hypertension [1.33 (1.07-1.64), Ptrend <0.01]. Likewise, a 1-SD increase in VVV of the TyG index was associated with an 11% excess risk of incident hypertension [1.11 (1.02-1.21)]. However, no association was found between the VVV of the TyG index and other outcomes. Moreover, the impact of index-year and average values of the TyG index was more prominent among women regarding incident CVD (P for interactions < 0.05).
CONCLUSIONS: Although the higher TyG index at index-year and its VVV were only associated with the incident T2DM and hypertension, respectively, its average value was capable of capturing the risk for all of the health outcomes.