背景:先前的研究表明,炎症和抗氧化剂的饮食模式可以改变COPD的风险,然而,很少有研究检查这些饮食与其早期症状的关联(PRISm),代谢紊乱的潜在作用仍有待阐明。
方法:分析了参加2007-2012年国家健康与营养调查(NHANES)的9529名个体的数据。饮食炎症指数(DII)和饮食抗氧化剂综合指数(CDAI)使用24小时饮食回忆进行评估,根据生化指标计算多个代谢指标,和肺功能参数定义的PRISm病例。通过广义线性模型和二元逻辑回归模型评估DII和CDAI的个体和联合效应,并通过因果中介分析进一步探讨代谢指标的中介效应。
结果:DII增加与肺功能降低(FEV1:β=-18.82,FVC:β=-29.2;OR=1.04)和代谢指标增加(MAP的β=0.316、0.036、0.916、0.033和0.145,UA,TC,TyG,MS,分别)。与此相反,CDAI与肺功能(FEV1:β=3.42;FVC:β=4.91;PRISm:OR=0.99)和代谢指标(β<0)呈正相关和负相关,分别。DII和CDAI的联合作用表明DII对TyG的危害最小(β=-0.11),FEV1(β=72.62),FVC(β=122.27),和PRISm(OR=0.79)与低CDAI的受试者相比(低DII高CDAIvs.高DII+低CDAI)。此外,TyG介导13.74%,8.29%,和21.70%的DII-和37.30%,20.90%,和12.32%的CDAI-FEV1,-FVC,和-PRISM协会,分别。
结论:这些发现表明CDAI可以减轻DII对代谢紊乱和肺功能下降的不利影响。这为饮食调整在预防早期肺功能障碍方面提供了新的见解。
BACKGROUND: Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few studies have examined the association of these diets with its early signs (PRISm), and the potential role of metabolic disorders remains to be elucidated.
METHODS: Data from 9529 individuals who participated in the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were analyzed. The Dietary Inflammation Index (DII) and the Dietary Antioxidant Composite Index (CDAI) were assessed using 24-h dietary recall, multiple metabolic indicators were calculated according to biochemical markers, and lung function parameters defined PRISm cases. Individual and joint effects of DII and CDAI were evaluated by generalized linear models and binary logistic regression models, and mediation effects of metabolic indicators were further explored by causal mediation analysis.
RESULTS: Increased DII was associated with decreased lung function (FEV1: β = -18.82, FVC: β = -29.2; OR = 1.04) and increased metabolic indicators (β = 0.316, 0.036, 0.916, 0.033, and 0.145 on MAP, UA, TC, TyG, and MS, respectively). Contrary to this, CDAI were positively and negatively associated with lung function (FEV1: β = 3.42; FVC: β = 4.91; PRISm: OR = 0.99) and metabolic indicators (β < 0), respectively. Joint effects of DII and CDAI indicated the minimal hazard effects of DII on TyG (β = -0.11), FEV1 (β = 72.62), FVC (β = 122.27), and PRISm (OR = 0.79) in subjects with high CDAI when compared with those with low CDAI (low DII + high CDAI vs. high DII + low CDAI). Furthermore, TyG mediated 13.74 %, 8.29 %, and 21.70 % of DII- and 37.30 %, 20.90 %, and 12.32 % of CDAI-FEV1, -FVC, and -PRISm associations, respectively.
CONCLUSIONS: These findings indicated that CDAI can attenuate the adverse effects of DII on metabolic disorders and lung function decline, which provides new insight for diet modification in preventing early lung dysfunction.