■研究白内障手术人群中泪膜高渗透压与眼部光散射之间的关联。
■连续,在白内障核混浊≥3的高渗性(≥320mOsm/L)和正常受试者(<308mOsm/L)中记录20秒客观散射指数(OSI)扫描。OSI是在筛选时测量的,基线和手术后90天。除了眼表疾病的症状,裂隙灯检查包括角膜染色(0-3),泪膜破裂时间(TBUT)和睑板腺疾病(MGD)的评估。在筛选时测量了另外一组高渗性受试者的OSI,基线,以及滴注0.18%透明质酸钠(HA)后5、10、15和30分钟。
■纳入31例患者的31只眼。当将高渗性(0.65±0.30,N=11)与正常人(0.33±0.11,N=10,p=0.005)进行比较时,术后OSI变化存在显着差异。值得注意的是,当通过染色对受试者进行排序时,OSI变异没有显着差异(p=0.9),TBUT(p=0.7),症状(p=0.7),或MGD状态(p=0.9)。滴注0.18%HA(N=10)在5分钟时没有改变OSI,但OSI大幅下降28.8%,在10、15和30分钟时观察到38.5%和36.7%(所有p<0.001)。
■高渗性患者在白内障手术后表现出光散射变化显著增加,但未通过染色或TBUT分化。渗透压升高可能表明光散射相当于2-3级白内障。
UNASSIGNED: To study the association between tear film hyperosmolarity and ocular light scatter in a cataract surgery population.
UNASSIGNED: Contiguous, 20-second objective scatter index (OSI) scans were recorded in hyperosmolar (≥320 mOsm/L) and normal subjects (<308 mOsm/L) with cataract nuclear opacity ≥3. OSI was measured at screening, baseline and 90 days following surgery. Along with symptoms of ocular surface disease, slit-lamp examination included corneal staining (0-3), tear film breakup time (TBUT) and evaluation of meibomian gland disease (MGD). An additional cohort of hyperosmolar subjects were measured for OSI at screening, baseline, and 5, 10, 15 and 30 minutes following instillation of 0.18% sodium hyaluronate (HA).
UNASSIGNED: Thirty-one eyes of 31 patients were included. There was a significant difference in post-operative OSI variation when comparing hyperosmolar (0.65±0.30, N=11) to normal subjects (0.33±0.11, N=10, p=0.005). Of note, there were no significant differences in OSI variation when subjects were sorted by staining (p=0.9), TBUT (p=0.7), symptoms (p=0.7), or MGD status (p=0.9). Instillation of 0.18% HA (N=10) did not alter OSI at 5 minutes, but significant reductions in OSI of 28.8%, 38.5% and 36.7% (all p < 0.001) were observed at 10, 15 and 30 minutes.
UNASSIGNED: Hyperosmolar patients exhibited significantly increased variation in light scatter following cataract surgery that was undifferentiated by staining or TBUT. Elevated osmolarity may be indicative of light scatter equivalent to that of a grade 2-3 cataract.