手术部位感染是常见且昂贵的感染,可导致死亡或患者预后不良。为了预防这些感染,使用抗生素预防。然而,抗生素的过度使用与更高的成本和抗生素耐药性的出现有关.
■本荟萃分析旨在比较单剂量与几种剂量抗生素在预防手术部位感染发展方面的有效性。
■PubMed被用于寻找临床试验,评估单剂量与几种剂量抗生素在避免手术部位感染发展方面的有效性。该研究包括1984年至2022年之间发表的试验。分析中纳入了74项临床试验。使用几率来比较具有95%置信区间的组。使用OR显示数据以生成森林图。使用ReviewManager(RevMan5.4版)进行荟萃分析。
■关于清洁操作,单剂量组5,634例患者中有389例手术部位感染(6.90%),多剂量组5,621例患者中有349例手术部位感染(6.21%)(OR=1.11,lowerCI=0.95,upperCI=1.30).关于清洁污染的操作,单剂量组2,715例患者中有137例手术部位感染(5.05%),多剂量组2,355例患者中有137例手术部位感染(5.82%)(OR=0.87,lowerCI=0.68,upperCI=1.11).关于受污染的操作,单剂量组3,262例患者中有302例手术部位感染(9.26%),多剂量组3,212例患者中有276例手术部位感染(8.59%)(OR=1.11,lowerCI=0.84,upperCI=1.47).总的来说,单剂量组11,611例患者中有828例手术部位感染(7.13%),多剂量组11,188例患者中有762例手术部位感染(6.81%)(OR=1.05,lowerCI=0.93,upperCI=1.20).组间差异不显著。
■本研究表明,使用单剂量抗菌药物预防与使用多剂量抗生素在减少手术部位感染方面同样有效。
UNASSIGNED: Surgical site infections are common and expensive infections that can cause fatalities or poor patient outcomes. To prevent these infections, antibiotic prophylaxis is used. However, excessive antibiotic use is related to higher costs and the emergence of antimicrobial resistance.
UNASSIGNED: The present meta-analysis aimed to compare the effectiveness of a single dosage versus several doses of antibiotics in preventing the development of surgical site infections.
UNASSIGNED: PubMed was used to find clinical trials evaluating the effectiveness of a single dosage versus several doses of antibiotics in avoiding the development of surgical site infections. The study included trials that were published between 1984 and 2022. Seventy-four clinical trials were included in the analysis. Odds ratios were used to compare groups with 95% confidence intervals. The data were displayed using OR to generate a forest plot. Review Manager (RevMan version 5.4) was used to do the meta-analysis.
UNASSIGNED: Regarding clean operations, there were 389 surgical site infections out of 5,634 patients in a single dose group (6.90%) and 349 surgical site infections out of 5,621 patients in multiple doses group (6.21%) (OR = 1.11, lower CI = 0.95, upper CI = 1.30). Regarding clean-contaminated operations, there were 137 surgical site infections out of 2,715 patients in a single dose group (5.05%) and 137 surgical site infections out of 2,355 patients in multiple doses group (5.82%) (OR = 0.87, lower CI = 0.68, upper CI = 1.11). Regarding contaminated operations, there were 302 surgical site infections out of 3,262 patients in a single dose group (9.26%) and 276 surgical site infections out of 3,212 patients in multiple doses group (8.59%) (OR = 1.11, lower CI = 0.84, upper CI = 1.47). In general, there were 828 surgical site infections out of 11,611 patients in a single dose group (7.13%) and 762 surgical site infections out of 11,188 patients in multiple doses group (6.81%) (OR = 1.05, lower CI = 0.93, upper CI = 1.20). The difference between groups was not significant.
UNASSIGNED: The present study showed that using a single-dose antimicrobial prophylaxis was equally effective as using multiple doses of antibiotics in decreasing surgical site infections.