背景:腺泡细胞癌(AciCC)是一种罕见的临床实体和唾液腺恶性肿瘤。它与细胞形态学模式的广泛组织学变化有关。
方法:对2002年至2023年诊断为AciCC的60例进行了不同细胞形态学模式的评估。
结果:诊断时患者的平均年龄为44.35±16.8岁,范围为15至81岁。女性占58.3%,F:M比为1.4:1。53例(88.3%)发生在腮腺,鼻区2例(3.3%),软板和上唇各一例(1.7%)。其余三个案件的地点没有具体说明。最常见的主诉是与疼痛相关的明确定义的面部肿胀。平均肿瘤大小为3.8±1.9cm。最主要的建筑模式是固体(83.3%),其次是微囊(60%),然后是卵泡(41.7%),乳头状囊性(14.3%),和肾小管囊性(28.6%),在3例(5%)中报告了具有去分化/高级转化的AcyCC。在83.3%的病例中(60人中有50人),我们注意到两种或多种生长模式的混合。其他退行性改变包括突出的淋巴间质,出血,和囊性改变。
结论:对AcCC的多种细胞形态学模式的认识和识别,特别是在发展中国家的机构中,高度特异性和敏感的免疫组织化学染色或分子诊断的可用性有限,是关键和必要的。
BACKGROUND: Acinic cell carcinoma (AciCC) is a rare clinical entity and a salivary gland malignancy. It is associated with wide histological variations in the cytomorphological patterns.
METHODS: Sixty cases diagnosed as AciCC from 2002 to 2023 were assessed for diverse cytomorphological patterns.
RESULTS: The mean age of patients at the time of diagnosis was 44.35±16.8 years ranging from 15 to 81 years. Females comprised 58.3% for a F: M ratio of 1.4:1. Fifty three cases (88.3%) occurred in the parotid gland, two cases in the nasal region (3.3%), and one case each in the soft plate and upper lip (1.7%). The location of the remaining three cases was not specified. The most common presenting complaint was a well-defined facial swelling associated with pain. The average tumor size was 3.8±1.9 cm. The most predominant architectural pattern was solid (83.3%) followed by microcystic (60%), then follicular (41.7%), papillary cystic (14.3%), and tubulocystic (28.6%), and AciCC with de-differentiation/high-grade transformation was reported in three cases (5%). In 83.3% of the cases (50 out of 60), we noticed a mixture of two or more growth patterns. Other degenerative changes included prominent lymphoid stroma, hemorrhage, and cystic change.
CONCLUSIONS: Awareness and recognition of diverse cytomorphological patterns of AciCC, especially in institutions of a developing country where there is limited availability of highly specific and sensitive immunohistochemical stains or molecular diagnostics, are crucial and essential.