A transition from nonhuman animal models to engineered microphysiological systems (MPS), such as organoids and organ-on-a-chip technologies, would signal a paradigm shift in biomedical research. Despite MPS\' potential to more accurately model human physiology, reduce high failure rates of drugs in clinical trials, and limit unnecessary animal use, widespread adoption is hampered by public opinion and lack of scalability, standardization, and current regulatory uptake. This article suggests how 5 key concepts (awareness, access, education, application, and rewards) could help address these barriers. These concepts are part of a framework that underscores a need to integrate MPS into mainstream biomedical research and to better promote ethical responsibility for the means of biomedical innovation.

Despite growing scientific alarm about anthropogenic climate change, the world is not on track to solve the crisis. Inaction may be partially explained by skepticism about climate change and resistance to proenvironmental policies from people who are motivated to maintain the status quo (i.e., conservative-rightists). Therefore, practical interventions are needed. In the present research program, we tested an experimental manipulation derived from system justification theory in which proenvironmental initiatives were framed as patriotic and necessary to maintain the American \"way of life.\" In a large, nationally representative U.S. sample, we found that the system-sanctioned change intervention successfully increased liberal-leftists\' as well as conservative-rightists\' belief in climate change; support for proenvironmental policies; and willingness to share climate information on social media. Similar messages were effective in an aggregated analysis involving 63 countries, although the overall effect sizes were small. More granular exploratory analyses at the country level revealed that while the intervention was moderately successful in some countries (e.g., Brazil, France, Israel), it backfired in others (Germany, Belgium, Russia). Across the three outcome variables, the effects of the intervention were consistent and pronounced in the United States, in support of the hypothesis that system justification motivation can be harnessed on behalf of social change. Potential explanations for divergent country-level effects are discussed. The system-sanctioned change intervention holds considerable promise for policymakers and communicators seeking to increase climate awareness and action.

UNASSIGNED: University emergencies, garnering significant public attention and shaping network opinions, pose a crucial challenge to universities\' management and societal stability. Hence, network public opinion on university emergencies is a vital issue. Nevertheless, the underlying mechanism has not been fully explored and cannot be efficiently controlled. This study aimed to explore the formation pattern of network public opinion on university emergencies, analyze its causes, and provide scientific governance strategies for coping with this issue.
UNASSIGNED: Based on a sample set of 204 cases from the Zhiwei Data Sharing Platform, this study classifies network public opinion on university emergencies into six types and visually analyzes their characteristics: time distribution, subject, duration, and emotion. By integrating the theory of the network public opinion field, this study develops a network public opinion field model of university emergencies to reveal its formation pattern. Furthermore, it analyzes the causes of network public opinion on university emergencies from the perspective of the public opinion lifecycle and proposes corresponding governance strategies.
UNASSIGNED: The sample consisted of 304 cases of real-life public opinion, and the visualization results show that public opinion on mental health and teacher-student safety constitutes the predominant types, accounting for 83.3%. High-occurrence subjects are public universities (88.24%) and students (48%). The most frequent months are July and December. 90.20% of the public opinions have a lifespan of less than 19 days, with an impact index ranging from 40 to 80. The public\'s emotional response to different types of public opinion varies, with negative emotions dominating.
UNASSIGNED: This study provides novel insights for understanding their formation and dissemination. It also provides practical implications for relevant departments to govern network public opinion on university emergencies.

BACKGROUND: The COVID-19 pandemic was a public health emergency (PHE) of unprecedented magnitude and impact. It provided the possibility to investigate the Dutch citizens\' understanding and perception of the actors involved in the Dutch pandemic response as a PHE unfolded.
METHODS: Three focus groups (FGs) were held with 16 Dutch citizens in June 2020. Citizens were recruited using the Dutch Health Care Consumer Panel. During the FGs, participants were asked to fill in a table with actors they thought were involved in the management of the COVID-19 pandemic. They also received information on actors involved in Dutch outbreak responses. Then, the actors named and omitted by the participants were discussed.
RESULTS: An analysis of the FGs suggests that the Dutch citizens participating in the study were not fully aware of the scope of actors involved in the Dutch COVID-19 pandemic response. Some participants would have appreciated more information on the actors involved. This would help them have an informed opinion of the actors involved in the decision-making process, and accept non-pharmaceutical interventions implemented. Lastly, most participants recognised that they played a role in limiting the spread of the COVID-19 pandemic. Yet, very few spontaneously mentioned themselves as actors within the COVID-19 pandemic response.
CONCLUSIONS: This study suggests that early in the COVID-19 pandemic, the Dutch citizens participating in this study\'s FG did not have a complete understanding of the scope of actors involved in the Dutch COVID-19 pandemic response, or the potential role of the citizen. Future research can build on these results to explore the citizen\'s perception of their role during PHEs of another origin, as well as other geographical and historical contexts.
UNASSIGNED: The public participated in the focus groups and received a non-expert report summarising the outcomes of the focus groups.

BACKGROUND: Examining support for substance use policies, including those for harm reduction, among the general public and policy influencers is a fundamental step to map the current policy landscape and leverage policy opportunities. Yet, this is a knowledge gap in Canada. Our paper identifies the level of support for substance use policies in two provinces in Canada and describes how the level of support is associated with intrusiveness and sociodemographic variables.
METHODS: Data came from the 2019 Chronic Disease Prevention Survey. The representative sample included members of the general public (Alberta n = 1648, Manitoba n = 1770) as well as policy influencers (Alberta n = 204, Manitoba n = 98). We measured the level of support for 22 public policies concerning substance use through a 4-point Likert-scale. The Nuffield Council on Bioethics Intervention Ladder framework was applied to assess intrusiveness. We used cumulative link models to run ordinal regressions for identification of explanatory sociodemographic variables.
RESULTS: Overall, there was generally strong support for the policies assessed. The general public in Manitoba was significantly more supportive of policies than its Alberta counterpart. Some differences were found between provinces and samples. For certain substance use policies, there was stronger support among women than men and among those with higher education than those with less education.
CONCLUSIONS: The results highlight areas where efforts are needed to increase support from both policy influencers and general public for adoption, implementation, and scaling of substance use policies. Socio-demographic variables related to support for substance use policies may be useful in informing strategies such as knowledge mobilization to advance the policy landscape in Western Canada.

Undercover videos have become a popular tool among NGOs to influence public opinion and generate engagement for the NGO\'s cause. These videos are seen as a powerful and cost-effective way of bringing about social change, as they provide first-hand evidence and generate a strong emotional response among those who see them. In this paper, we empirically assess the impact of undercover videos on support for the cause. We in addition analyze whether the increased engagement among viewers is driven by the negative emotional reactions produced by the video. To do so, we design an online experiment that enables us to estimate both the total and emotion-mediated treatment effects on engagement by randomly exposing participants to an undercover video (of animal abuse) and randomly introducing a cooling-off period. Using a representative sample of the French population (N=3,310), we find that the video successfully increases actions in favor of animals (i.e., donations to NGOs and petitions), but we fail to prove that this effect is due to the presence of primary emotions induced by the video. Last, we investigate whether activists correctly anticipate their undercover videos\' (emotional) impact via a prediction study involving activists (exploratory analysis). PROTOCOL REGISTRATION: This manuscript is a Stage-2 working paper of a Registered Report that received In-Principle-Acceptance from Scientific Reports on November 20th, 2023 [ Link to Stage-1 ]. The Stage-1 that received In-Principal-Acceptance can be found here: https://osf.io/8cg2d .

Immigration is one of the most salient topics in public debate. Social media heavily influences opinions on immigration, often sparking polarized debates and offline tensions. Studying 220,870 immigration-related tweets in the UK, we assessed the extent of polarization, key content creators and disseminators, and the speed of content dissemination. We identify a high degree of online polarization between pro and anti-immigration communities. We found that the anti-migration community is small but denser and more active than the pro-immigration community with the top 1% of users responsible for over 23% of anti-immigration tweets and 21% of retweets. We also discovered that anti-immigration content spreads also 1.66 times faster than pro-immigration messages and bots have minimal impact on content dissemination. Our findings suggest that identifying and tracking highly active users could curb anti-immigration sentiment, potentially easing social polarization and shaping broader societal attitudes toward migration.

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BACKGROUND: Supervised injecting facilities (SIF) have been shown to reduce negative outcomes experienced by people who inject drugs. They are often subject to intense public and media scrutiny. This article aimed to explore population attitudes to SIFs and how these changed over time in Australia.
METHODS: Data were drawn from the National Drug Strategy Household Survey, a national sample collecting data on illicit drug use and attitudes towards drug policy among Australians (2001-2019). Ordinal logistic regression assessed sociodemographic characteristics associated with different attitudes to SIFs and binary logistic regression assessed trends over time and by jurisdiction.
RESULTS: In 2019, 54% of respondents (95% CI 52.9, 55.1) supported SIFs, 27.5% (95% CI 26.6, 28.4) opposed and 18.4% (95% CI 17.7, 19.2) were ambivalent. Support for SIFs correlated with having a university degree (OR 1.75; 95% CI 1.58, 1.94), non-heterosexual identity (OR 1.81, 95% CI 1.51, 2.17) and recent illicit drug use (OR = 1.74, 95% CI 1.55, 1.94). Male respondents or those living in socioeconomically disadvantaged areas had lower odds of supporting SIFs (OR 0.92, 95% CI 0.85, 1.00; OR 0.64-0.80, respectively). Between 2001 and 2019, support for SIFs increased modestly by 3.3%, those who \'don\'t know\' by 7.4%, whereas opposition decreased by 11.7%. Between 2001 and 2019, support for SIFs increased in NSW and Queensland, whereas opposition decreased in all jurisdictions.
CONCLUSIONS: Opposition to SIFs declined over the past 20 years, but a substantial proportion of respondents are ambivalent or \'don\'t know enough to say\'. Plain language information about SIFs and their potential benefits, targeted to those who are ambivalent/\'don\'t know\' may further increase public support.