pain catastrophizing

疼痛灾难化
  • 文章类型: Journal Article
    根据进化心理学家的说法,一个有意识地或不有意识地分配用于躯体努力的资源的个体专注于稳态和对自己和他人的保护。在健康危机期间,患者必须在动员剩余资源以康复或不可避免地接受疾病之间做出选择。当患者选择积极主动地保护自己的健康时,是认真的,并且在恢复过程中合规,实现了高水平的患者激活。因此,我们检查了(N=252)患者的K适应策略是否是参与患者激活型行为的预测因子.此外,我们测试了痛苦灾难化的中介作用和浪漫满意度的调节作用。我们发现有医学诊断的人,他们在一段浪漫的关系中,并且具有高K适应性的患者更有可能被激活。此外,疼痛灾难化介导了高K健身策略与患者激活之间的关系,虽然浪漫的满足感缓和了这段关系,放大它的强度。研究结果强调了识别患者心理资源的重要性(例如,高K策略,浪漫的满足,或疼痛感知),让他们参与健康恢复过程。
    According to evolutionary psychologists, an individual-consciously or not-who allocates resources for somatic effort focuses on homeostasis and the protection of themselves and others. During health crises, patients must choose between mobilizing their remaining resources to either recover or accepting the disease as inevitable. When patients choose to be proactive in terms of protecting their health, are conscientious, and compliant in the recovery process, a high level of patient activation is achieved. Therefore, we examined (N = 252) whether the patients\' K fitness strategies are predictors for engagement in patient activation-type behavior. In addition, we tested the mediating effect of pain catastrophizing and the moderating effect of romantic satisfaction. We found that people with a medical diagnosis, who were in a romantic relationship, and had high-K fitness were much more likely to be activated patients. Moreover, pain catastrophizing mediated the relationship between high-K fitness strategy and patient activation, while romantic satisfaction moderated this relationship, amplifying its intensity. The findings highlight the importance of identifying patients\' psychological resources (e.g., high-K strategy, romantic satisfaction, or pain perception) to keep them engaged in the health recovery process.
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  • 文章类型: Journal Article
    目的:触觉敏锐度是人类可以辨别触觉刺激程度的体感量度。它受到外围信号集中处理方式的影响。在口腔中,咬合触觉敏锐度(OTA)是感知拮抗牙齿之间最小厚度的能力。本研究的目的是评估心理特征与健康个体的OTA之间的关联。
    方法:63名志愿者(32名男性;平均年龄±SD:24.6±2.7岁)参加了这项研究。体感放大,焦虑,抑郁症,使用问卷对身体症状和疼痛灾难进行评分,和严重性亚组根据截止值创建每个变量。使用9个具有厚度(范围从8至72μm)的铝箔和一个假测试(没有箔)测量OTA。每个厚度按随机顺序测试10次,参与者被指示报告他们是否感觉到磨牙之间的摩擦,并计算正确答案的平均百分比。线性混合模型以OTA为因变量,心理域为自变量。
    结果:在焦虑亚组之间观察到明显不同的OTA(p=0.003),与没有/轻度焦虑的参与者相比,中度/重度焦虑的参与者对厚度24和32μm的感知降低(分别为p=.018和p<.001)。在疼痛灾难亚组中也观察到显著不同的OTA(p=.008),在严重的灾难水平下,显示厚度32和40μm(分别为p<.001和p=.007)的感知降低,与无/轻度灾难水平相比。其他变量没有观察到显著差异。
    结论:与轻度或无心理障碍的参与者相比,焦虑或疼痛灾难程度增加的健康成年人显示出降低的齿间敏度。
    OBJECTIVE: Tactile acuity is a somatosensory measure of the extent to which humans can discern tactile stimuli. It is influenced by how peripheral signals are processed centrally. In the oral cavity, Occlusal Tactile Acuity (OTA) is the ability to perceive minimal thicknesses between antagonist teeth. The aim of the current study was to assess the association between psychological traits and OTA of otherwise healthy individuals.
    METHODS: Sixty-three volunteers (32 males; mean age ± SD: 24.6 ± 2.7 years) participated in this study. Somatosensory amplification, anxiety, depression, physical symptoms and pain catastrophizing were scored using questionnaires, and subgroups of severity were created per variable based on cut-offs. OTA was measured using 9 aluminium foils with thickness (ranging from 8 to 72 μm) and one sham test (without foil). Each thickness was tested 10 times in random order, the participants were instructed to report whether they felt the foil between their molars and the mean percentage of correct answers was computed. A linear mixed model was used with OTA as a dependent variable and psychological domain as an independent variable.
    RESULTS: Significantly different OTA was observed among the anxiety subgroups (p = .003), supporting a decreased perception of thicknesses 24 and 32 μm (p = .018 and p < .001, respectively) in participants with moderate/severe anxiety compared to those with no/mild anxiety. Significantly different OTA was also observed among the pain catastrophizing subgroups (p = .008), showing decreased perception of thicknesses 32 and 40 μm (p < .001 and p = .007, respectively) in severe catastrophizing levels, compared to no/mild catastrophizing levels. No significant differences were observed for the other variables.
    CONCLUSIONS: Healthy adults with increased anxiety or pain catastrophizing levels show decreased interdental acuity as compared to participants with minor or no psychological impairment.
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  • 文章类型: Journal Article
    过度的肌肉共收缩是与膝骨关节炎(OA)进展相关的因素之一。之前的一项研究表明,疼痛,关节不稳定性,侧向推力,体重,和下肢对齐被列为影响膝关节OA过度收缩的因素。然而,本研究旨在评估膝关节OA患者在步态和爬楼梯过程中避免恐惧信念与肌肉共收缩之间的关系.24名膝关节OA患者参加了这项横断面研究。共收缩比(CCR)用于计算步行和爬楼梯过程中的肌肉共收缩,使用表面肌电图。通过运动恐惧症的Tampa量表-11(TSK-11)评估运动恐惧症,并通过疼痛灾难化量表(PCS)评估避免恐惧的信念。可能影响共同收缩的次要参数,例如疼痛程度,侧向推力,体重,和下肢对齐,被测量。在每个运动过程中CCR之间的关系,TSK-11和PSC采用Spearman秩相关系数和偏相关分析进行评估,通过重量和下肢对齐来调整。偏相关分析表明,在楼梯下降过程中,内侧肌CCR与TSK-11之间存在显着相关性(r=0.54,p<0.05)。我们的研究表明,膝关节OA患者在楼梯下降过程中运动恐惧症可能与共同收缩有关。
    Excessive muscle co-contraction is one of the factors related to the progression of knee osteoarthritis (OA). A previous study demonstrated that pain, joint instability, lateral thrust, weight, and lower extremity alignment were listed as factors affecting excessive co-contraction in knee OA. However, this study aimed to assess the association between fear-avoidance beliefs and muscle co-contraction during gait and stair climbing in people with knee OA. Twenty-four participants with knee OA participated in this cross-sectional study. Co-contraction ratios (CCRs) were used to calculate muscle co-contraction during walking and stair climbing, using surface electromyography. Fear-avoidance beliefs were assessed by the Tampa Scale for Kinesiophobia-11 (TSK-11) for kinesiophobia and the Pain Catastrophizing Scale (PCS) for pain catastrophizing. Secondary parameters that may influence co-contraction, such as degree of pain, lateral thrust, weight, and lower extremity alignment, were measured. The relationships between the CCR during each movement, TSK-11, and PSC were evaluated using Spearman\'s rank correlation coefficient and partial correlation analysis, adjusted by weight and lower extremity alignment. Partial correlation analysis showed a significant correlation only between medial muscles CCR and TSK-11 during stair descent (r = 0.54, p < 0.05). Our study revealed that kinesiophobia could be associated with co-contraction during stair descent in people with knee OA.
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  • 文章类型: Journal Article
    这项研究旨在确定全膝关节置换术(TKA)后老年患者的疼痛韧性与疼痛灾难之间的关系是否由认知情绪调节策略(CERS)和疼痛管理自我效能感(PMSE)介导。在这项横断面研究中使用了便利整群抽样来招募382名老年人。结果显示,疼痛灾难化与疼痛韧性呈负相关,自适应CERS,和PMSE;然而,与适应不良的CERS呈正相关(均p<0.01)。中介分析显示,CERS(适应性和适应性不良)和自我管理独立且依次介导了接受TKA的老年患者的疼痛韧性和疼痛灾难之间的关系。这些发现表明,CERS(适应性和适应性不良)和PMSE在TKA术后老年患者的疼痛弹性和疼痛灾难之间的相关性中起着链介导作用。
    This study aimed to determine whether the relationship between pain resilience and pain catastrophizing in older patients after total knee arthroplasty (TKA) was mediated by cognitive emotion regulation strategies (CERS) and pain management self-efficacy (PMSE). Convenience cluster sampling was used in this cross-sectional study to recruit 382 older adults. The results revealed that pain catastrophizing was negatively correlated with pain resilience, adaptive CERS, and PMSE; however, it was positively correlated with maladaptive CERS (all p < 0.01). Mediation analysis revealed that both CERS (adaptive and maladaptive) and self-management independently and sequentially mediated the relationship between pain resilience and pain catastrophizing in older patients who underwent TKA. These findings demonstrate that CERS (adaptive and maladaptive) and PMSE play chain-mediating roles in the correlation between pain resilience and pain catastrophizing in older patients after TKA.
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  • 文章类型: Journal Article
    疼痛会自动干扰正在进行的认知过程,例如注意力和记忆力。疼痛对认知功能的负面影响程度似乎取决于自上而下和自下而上因素之间的平衡。
    在这个大的,预注册,对8项研究进行汇总再分析,我们调查了急性疼痛对识别记忆的有害影响的鲁棒性,以及自上而下的机制,如疼痛相关的期望或认知(疼痛相关的恐惧,疼痛灾难化)调节这种效果。
    二百四十七个健康参与者经历了类似的实验范式,包括视觉分类任务,其中图像随机配对(或没有)伴随的疼痛刺激以及随后的未通知识别任务。识别记忆(即,d\',回忆,和熟悉度)和分类性能(即,反应时间,准确性)作为疼痛对认知能力影响的代理。
    急性疼痛刺激显着损害识别性能(d\',熟悉度)。然而,在该健康参与者样本中,参与者对疼痛对任务表现或疼痛相关认知的影响的预期并未显著调节识别表现.
    我们的研究结果证实了以前的研究和慢性疼痛患者的“记忆问题”报告中报道的疼痛对(视觉)记忆编码的负面影响。描述自下而上和自上而下因素对疼痛有害影响的作用,大规模的研究与更细致的研究设计是必要的。患者队列的未来研究必须揭示慢性疼痛患者的适应不良疼痛相关认知和经常报告的认知功能受损之间的相互作用。
    UNASSIGNED: Pain can automatically interfere with ongoing cognitive processes such as attention and memory. The extent of pain\'s negative effects on cognitive functioning seems to depend on a balance between top-down and bottom-up factors.
    UNASSIGNED: In this large, preregistered, pooled reanalysis of 8 studies, we investigated the robustness of the detrimental effect of acute pain on recognition memory and whether top-down mechanisms such as pain-related expectations or cognitions (pain-related fear, pain catastrophizing) modulate this effect.
    UNASSIGNED: Two hundred forty-seven healthy participants underwent similar experimental paradigms, including a visual categorization task with images randomly paired with (or without) concomitant painful stimulation and a subsequent unannounced recognition task. Recognition memory (ie, d\', recollection, and familiarity) and categorization performance (ie, reaction time, accuracy) served as proxies for the effect of pain on cognitive performance.
    UNASSIGNED: Acute painful stimulation significantly impaired recognition performance (d\', familiarity). However, recognition performance was not significantly modulated by participants\' expectations regarding the effect of pain on task performance or pain-related cognitions in this sample of healthy participants.
    UNASSIGNED: Our results corroborate the negative effects of pain on (visual) memory encoding reported in previous studies and reports of \"memory problems\" from patients with chronic pain. To characterize the role of bottom-up and top-down factors for the detrimental effects of pain, large-scale studies with more nuanced study designs are necessary. Future studies in patient cohorts must unravel the interaction of maladaptive pain-related cognitions and the often-reported impaired cognitive performance in chronic pain patients.
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  • 文章类型: Journal Article
    疼痛灾难化是对疼痛感觉的夸大关注。它可能是影响膝关节置换术疼痛和功能结局的独立因素。我们旨在评估膝关节置换术后长达一年的术前疼痛灾难与疼痛和功能结局之间的关系。我们使用了一项队列研究的数据,该研究对接受膝关节骨关节炎初次膝关节置换术(完全或单室关节置换术)的患者进行了研究。术前使用疼痛灾变量表(PCS)评估疼痛灾变。其他基线变量包括人口统计,身体质量指数,射线照相严重性,焦虑,抑郁症,使用西安大略省和麦克马斯特大学指数(WOMAC)评估膝关节疼痛和功能。患者在关节置换术后6个月和12个月完成了WOMAC。将WOMAC疼痛和功能评分转换为间隔量表,并在广义线性回归模型中评估PCS与WOMAC疼痛和功能变化的关联,并调整混杂变量。在1136例接受关节置换术的患者中(70%为女性,84%中国人,92%全膝关节置换术),1102和1089提供了术后6个月和12个月的数据。患者的平均(±SD)年龄为65.9(±7.0)岁。在多变量模型调整后,PCS与术后6个月和12个月WOMAC疼痛的变化相关(β=-0.04,95%置信区间:-0.06,-0.02;P<0.001);以及6个月和12个月WOMAC功能的变化。在这项大型队列研究中,术前疼痛灾难化与关节置换术后6个月和12个月疼痛和功能改善较低相关.
    Pain catastrophizing is an exaggerated focus on pain sensations. It may be an independent factor influencing pain and functional outcomes of knee arthroplasty. We aimed to evaluate the association between pre-operative pain catastrophizing with pain and function outcomes up to one year after knee arthroplasty. We used data from a cohort study of patients undergoing primary knee arthroplasty (either total or unicompartmental arthroplasty) for knee osteoarthritis. Pain catastrophizing was assessed pre-operatively using the Pain Catastrophizing scale (PCS). Other baseline variables included demographics, body mass index, radiographic severity, anxiety, depression, and knee pain and function assessed using the Western Ontario and McMaster University Index (WOMAC). Patients completed the WOMAC at 6- and 12-months after arthroplasty. WOMAC pain and function scores were converted to interval scale and the association of PCS and changes of WOMAC pain and function were evaluated in generalized linear regression models with adjustment with confounding variables. Of the 1136 patients who underwent arthroplasty (70% female, 84% Chinese, 92% total knee arthroplasty), 1102 and 1089 provided data at 6- and 12-months post-operatively. Mean (± SD) age of patients was 65.9 (± 7.0) years. PCS was associated with a change in WOMAC pain at both 6-months and 12-months (β = - 0.04, 95% confidence interval: - 0.06, - 0.02; P < 0.001) post-operatively after adjustment in multivariable models; as well as change in WOMAC function at 6-months and 12-months. In this large cohort study, pre-operative pain catastrophizing was associated with lower improvements in pain and function at 6-months and 12-months after arthroplasty.
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  • 文章类型: Journal Article
    背景:髌股疼痛(PFP)是一种常见的慢性疾病,其特征是各种基于膝关节屈曲的活动加剧了髌骨后或髌周疼痛。先前的研究强调了心理结构对慢性肌肉骨骼疼痛状况下疼痛和功能的影响,然而,它们对PFP队列中体力活动的影响仍未被探索。我们旨在评估疼痛自我效能感和疼痛灾难是否可以预测PFP患者每天步数的变化以及中度至剧烈的体育锻炼(MVPA)。
    方法:横断面观察性研究。
    方法:纳入了39名PFP患者(11名男性)。因变量是每天的步骤和MVPA的分钟数。独立变量是疼痛自我效能感和疼痛灾难,通过疼痛自我效能感问卷和疼痛灾难感量表进行测量。参与者被给予ActiGraphwGT3X-BT7天以评估身体活动。评估了心理措施和身体活动之间的相关性,并对与身体活动相关的心理变量进行了简单的线性回归。α被先验地设定为P<.05。
    结果:疼痛自我效能评分显示出与每天步数的中度关联(rho=.45,P=.004),与MVPA的弱关联(rho=.38,P=.014)。疼痛灾难评分与体力活动无显著相关性(P<0.05)。回归模型确认疼痛自我效能评分是每天两个步骤(F1,37=10.30,P=0.002)和MVPA(F1,37=8.98,P=0.004)的显着预测因子。
    结论:心理措施继续证明临床医生治疗PFP的价值。疼痛自我效能评分与每天的步数中度相关,与MVPA弱相关,解释了近五分之一的体力活动变化。临床医生在治疗PFP患者时,应优先评估疼痛自我效能感,可能采用心理干预措施来改善PFP人群的体育锻炼。
    BACKGROUND: Patellofemoral pain (PFP) is a prevalent chronic condition characterized by retropatellar or peripatellar pain exacerbated by various knee flexion-based activities. Previous research has highlighted the impact of psychological constructs on pain and function in chronic musculoskeletal pain conditions, yet their influence on physical activity in PFP cohorts remains unexplored. We aimed to evaluate whether pain self-efficacy and pain catastrophizing predict variations in steps per day and moderate to vigorous physical activity (MVPA) among individuals with PFP.
    METHODS: Cross-sectional observational study.
    METHODS: Thirty-nine participants (11 males) with PFP were included. Dependent variables were steps per day and minutes of MVPA. Independent variables were pain self-efficacy and pain catastrophizing, measured by the pain self-efficacy questionnaire and the pain catastrophizing scale. Participants were given an ActiGraph wGT3X-BT for 7 days to assess physical activity. Correlations were assessed between psychological measures and physical activity, and a simple linear regression was performed on psychological variables that correlated with physical activity. Alpha was set a priori at P < .05.
    RESULTS: Pain self-efficacy scores displayed a moderate association with steps per day (rho = .45, P = .004) and a weak association with MVPA (rho = .38, P = .014). Pain catastrophizing scores exhibited no significant associations with physical activity (P < .05). Regression models affirmed pain self-efficacy scores as significant predictors of both steps per day (F1,37 = 10.30, P = .002) and MVPA (F1,37 = 8.98, P = .004).
    CONCLUSIONS: Psychological measures continue to demonstrate value to clinicians treating PFP. Pain self-efficacy scores were moderately associated with steps per day and weakly associated with MVPA, explaining nearly a fifth of the variation in physical activity. Clinicians should prioritize the assessment of pain self-efficacy when treating individuals with PFP, potentially employing psychological interventions to improve physical activity in the PFP population.
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  • 文章类型: Journal Article
    适应性疼痛应对技能之间的关系,比如约翰·亨利主义,非西班牙裔黑人人群的疼痛和功能仍不清楚。这个横截面,观察性研究包括杰克逊维尔60名患有腰痛的老年黑人男性,佛罗里达关键指标是:过去24小时自我报告的0-10疼痛强度,13项痛苦灾难,BackPerformanceScale的功能性能,和约翰·亨利主义积极应对量表。结构方程模型应用于57个完整案例,使用Rv4.2.0进行分析。在老年黑人男性中,JohnHenryism(β=-0.320,p=.038)和疼痛灾难化(β=0.388,p=.007)与疼痛强度显着相关,但与功能表现无关(β=-0.095,p=.552;β=0.274,p=.068)。该研究强调了使用纵向方法评估约翰·亨利主义的未来重要性,以探索美国黑人之间复杂的结构方程模型的因果关系。
    The relationship between adaptive pain-coping skills, such as John Henryism, and pain and function remains unclear in non-Hispanic Black populations. This cross-sectional, observational study included sixty older Black men with low back pain in Jacksonville, Florida. Key measures were: self-reported 0-10 pain intensity in the past 24 h, 13-item pain catastrophizing, functional performance from the Back Performance Scale, and the John Henryism Active Coping Scale. Structural equation modeling was applied to 57 complete cases for analysis using R v4.2.0. There was a significant association for both John Henryism (β = -0.320, p = .038) and pain catastrophizing (β = 0.388, p = .007) with pain intensity but not functional performance (β = -0.095, p = .552; β = 0.274, p = .068, respectively) in the older Black men. The study underscores the future importance of evaluating John Henryism using longitudinal methods to explore causality with complex structural equation models among Black Americans.
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  • 文章类型: Journal Article
    本横断面研究的目的是检查心率变异性(HRV)与颈椎活动范围之间的关系,残疾,疼痛强度,痛苦的灾难,以及慢性病患者的生活质量,非特异性颈部疼痛。35个病人,20-48岁,慢性非特异性颈部疼痛,完成关于颈部疼痛强度的验证问卷,疼痛相关的残疾,灾难性的想法,和生活质量。使用数字测角仪评估颈椎运动的范围。HRV指数记录在三个位置(仰卧,坐着,和站立)通过智能手机应用程序。观察到HRV指数与颈部疼痛残疾之间存在一些显着相关性,灾难的无助因素,颈部旋转,和生活质量。这些相关性仅在站立姿势中观察到。疼痛灾难化与主动颈部运动时的残疾和疼痛强度呈正相关(Pearsonr=0.544,p<0.01;Pearsonr=0.605,p<0.01)。生活质量与主动运动时疼痛强度呈负相关(Pearsonr=-0.347,p<0.05)。HRV指数与颈部疼痛的心理和生理领域相关。在一些先前的研究中,这些心脏指数与颈部疼痛变量有关。需要进一步的研究来证实这种关系在不同的日常条件。
    The purpose of the present cross-sectional study was to examine the relationship between heart rate variability (HRV) and the range of cervical motion, disability, pain intensity, pain catastrophizing, and quality of life in patients with chronic, non-specific neck pain. Thirty-five patients, aged 20-48 years, with chronic non-specific neck pain, completed validated questionnaires regarding neck pain intensity, pain-associated disability, catastrophic thoughts, and quality of life. The range of cervical motion was assessed using a digital goniometer. HRV indices were recorded in three positions (supine, sitting, and standing) through a smartphone application. Several significant correlations were observed between HRV indices and neck pain disability, the helplessness factor of catastrophizing, neck rotation, and quality of life. These correlations were only observed in the standing position. Pain catastrophizing was positively correlated with disability and pain intensity during active neck movement (Pearson r = 0.544, p < 0.01; Pearson r = 0.605, p < 0.01, respectively). Quality of life was negatively correlated with pain intensity during active movement (Pearson r = -0.347, p < 0.05). HRV indices were correlated with the psychological and physical domains of neck pain. These cardiac indices have been related to neck pain variables in some previous studies. Further research is needed to confirm this relationship in different daily conditions.
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  • 文章类型: Journal Article
    目的:本研究旨在探讨无阿片类药物麻醉(OFA)在腹腔镜胃切除术中的效果,并确定可能影响OFA疗效的心理因素。
    方法:120例腹腔镜胃切除术患者被分为阿片类药物麻醉组(OA)(n=60)或OFA组(n=60)。OA组术中给予瑞芬太尼,OFA组给予右美托咪定和利多卡因。使用对齐秩变换进行非参数阶乘分析,分析了心理因素对OFA的交互作用。
    结果:OFA组术后24小时的阿片类药物需求量低于OA组(芬太尼等效剂量727与650μg,p=0.036)。OFA的效果受疼痛灾难量表的影响(p=0.041),颞部疼痛总和(p=0.046),和压力疼痛耐受性(p=0.034)。这表明疼痛灾难化或高疼痛敏感性的患者从OFA中显著受益,而没有这些特征的患者没有。
    结论:这项研究表明,右美托咪定和利多卡因的OFA有效降低了腹腔镜胃切除术后24小时阿片类药物的需求,通过基线疼痛灾难化和疼痛敏感性对其进行了修改。
    背景:该研究方案由延世大学卫生系统江南遣散医院(#3-2021-0295)的机构审查委员会批准,并在ClinicalTrials.gov(NCT05076903)注册。
    OBJECTIVE: This study aimed to investigate the effects of opioid-free anesthesia (OFA) in laparoscopic gastrectomy and identify the psychological factors that could influence the efficacy of OFA.
    METHODS: 120 patients undergoing laparoscopic gastrectomy were allocated to either the opioid-based anesthesia group (OA) (n = 60) or the OFA (n = 60) group. Remifentanil was administered to the OA group intraoperatively, whereas dexmedetomidine and lidocaine were administered to the OFA group. The interaction effect of the psychological factors on OFA was analyzed using the aligned rank transform for nonparametric factorial analyses.
    RESULTS: The opioid requirement for 24 h after surgery was lower in the OFA group than in the OA group (fentanyl equivalent dose 727 vs. 650 μg, p = 0.036). The effect of OFA was influenced by the pain catastrophizing scale (p = 0.041), temporal pain summation (p = 0.046), and pressure pain tolerance (p = 0.034). This indicates that patients with pain catastrophizing or high pain sensitivity significantly benefited from OFA, whereas patients without these characteristics did not.
    CONCLUSIONS: This study demonstrated that OFA with dexmedetomidine and lidocaine effectively reduced the postoperative 24-h opioid requirements following laparoscopic gastrectomy, which was modified by baseline pain catastrophizing and pain sensitivity.
    BACKGROUND: The study protocol was approved by the Institutional Review Board of Yonsei University Health System Gangnam Severance Hospital (#3-2021-0295) and registered at ClinicalTrials.gov (NCT05076903).
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