PDF(Pubmed)
Abstract：
UNASSIGNED: Pain can automatically interfere with ongoing cognitive processes such as attention and memory. The extent of pain\'s negative effects on cognitive functioning seems to depend on a balance between top-down and bottom-up factors.
UNASSIGNED: In this large, preregistered, pooled reanalysis of 8 studies, we investigated the robustness of the detrimental effect of acute pain on recognition memory and whether top-down mechanisms such as pain-related expectations or cognitions (pain-related fear, pain catastrophizing) modulate this effect.
UNASSIGNED: Two hundred forty-seven healthy participants underwent similar experimental paradigms, including a visual categorization task with images randomly paired with (or without) concomitant painful stimulation and a subsequent unannounced recognition task. Recognition memory (ie, d\', recollection, and familiarity) and categorization performance (ie, reaction time, accuracy) served as proxies for the effect of pain on cognitive performance.
UNASSIGNED: Acute painful stimulation significantly impaired recognition performance (d\', familiarity). However, recognition performance was not significantly modulated by participants\' expectations regarding the effect of pain on task performance or pain-related cognitions in this sample of healthy participants.
UNASSIGNED: Our results corroborate the negative effects of pain on (visual) memory encoding reported in previous studies and reports of \"memory problems\" from patients with chronic pain. To characterize the role of bottom-up and top-down factors for the detrimental effects of pain, large-scale studies with more nuanced study designs are necessary. Future studies in patient cohorts must unravel the interaction of maladaptive pain-related cognitions and the often-reported impaired cognitive performance in chronic pain patients.
UNASSIGNED: In this large, preregistered, pooled reanalysis of 8 studies, we investigated the robustness of the detrimental effect of acute pain on recognition memory and whether top-down mechanisms such as pain-related expectations or cognitions (pain-related fear, pain catastrophizing) modulate this effect.
UNASSIGNED: Two hundred forty-seven healthy participants underwent similar experimental paradigms, including a visual categorization task with images randomly paired with (or without) concomitant painful stimulation and a subsequent unannounced recognition task. Recognition memory (ie, d\', recollection, and familiarity) and categorization performance (ie, reaction time, accuracy) served as proxies for the effect of pain on cognitive performance.
UNASSIGNED: Acute painful stimulation significantly impaired recognition performance (d\', familiarity). However, recognition performance was not significantly modulated by participants\' expectations regarding the effect of pain on task performance or pain-related cognitions in this sample of healthy participants.
UNASSIGNED: Our results corroborate the negative effects of pain on (visual) memory encoding reported in previous studies and reports of \"memory problems\" from patients with chronic pain. To characterize the role of bottom-up and top-down factors for the detrimental effects of pain, large-scale studies with more nuanced study designs are necessary. Future studies in patient cohorts must unravel the interaction of maladaptive pain-related cognitions and the often-reported impaired cognitive performance in chronic pain patients.
摘要：
■疼痛会自动干扰正在进行的认知过程，例如注意力和记忆力。疼痛对认知功能的负面影响程度似乎取决于自上而下和自下而上因素之间的平衡。
■在这个大的，预注册,对8项研究进行汇总再分析，我们调查了急性疼痛对识别记忆的有害影响的鲁棒性，以及自上而下的机制，如疼痛相关的期望或认知(疼痛相关的恐惧，疼痛灾难化）调节这种效果。
■二百四十七个健康参与者经历了类似的实验范式，包括视觉分类任务，其中图像随机配对（或没有）伴随的疼痛刺激以及随后的未通知识别任务。识别记忆(即，d\',回忆，和熟悉度)和分类性能(即，反应时间,准确性)作为疼痛对认知能力影响的代理。
■急性疼痛刺激显着损害识别性能（d\'，熟悉度)。然而,在该健康参与者样本中,参与者对疼痛对任务表现或疼痛相关认知的影响的预期并未显著调节识别表现.
■我们的研究结果证实了以前的研究和慢性疼痛患者的“记忆问题”报告中报道的疼痛对（视觉）记忆编码的负面影响。描述自下而上和自上而下因素对疼痛有害影响的作用，大规模的研究与更细致的研究设计是必要的。患者队列的未来研究必须揭示慢性疼痛患者的适应不良疼痛相关认知和经常报告的认知功能受损之间的相互作用。
■在这个大的，预注册,对8项研究进行汇总再分析，我们调查了急性疼痛对识别记忆的有害影响的鲁棒性，以及自上而下的机制，如疼痛相关的期望或认知(疼痛相关的恐惧，疼痛灾难化）调节这种效果。
■二百四十七个健康参与者经历了类似的实验范式，包括视觉分类任务，其中图像随机配对（或没有）伴随的疼痛刺激以及随后的未通知识别任务。识别记忆(即，d\',回忆，和熟悉度)和分类性能(即，反应时间,准确性)作为疼痛对认知能力影响的代理。
■急性疼痛刺激显着损害识别性能（d\'，熟悉度)。然而,在该健康参与者样本中,参与者对疼痛对任务表现或疼痛相关认知的影响的预期并未显著调节识别表现.
■我们的研究结果证实了以前的研究和慢性疼痛患者的“记忆问题”报告中报道的疼痛对（视觉）记忆编码的负面影响。描述自下而上和自上而下因素对疼痛有害影响的作用，大规模的研究与更细致的研究设计是必要的。患者队列的未来研究必须揭示慢性疼痛患者的适应不良疼痛相关认知和经常报告的认知功能受损之间的相互作用。
