背景:非酒精性脂肪性肝病(NAFLD)涉及肝脏脂肪过度积累,并与氧化应激密切相关,这有助于肝脏炎症和损伤。本研究旨在评估抗阻训练(RT)和维生素E补充剂(VES)等干预措施如何调节NAFLD的标志物和调节葡萄糖和脂质代谢的关键蛋白质。例如C1Q/TNF相关蛋白(CTRPs)。
方法:将40名NAFLD患者(平均年龄:32.4±8.2岁)随机分为四组,每组12周:安慰剂(PLB),VES,PLB+RT,和VES+RT。VES以800IU/天以双盲方式施用。RT方案包括八次练习,一次重复最大值(1RM)的60-80%,三组8-12次重复,每周执行三次。干预前和干预后的评估包括身体组成,天冬氨酸转氨酶(AST),丙氨酸氨基转移酶(ALT),血脂谱,血糖控制,CTRP-2、CTRP-9和1RM评估。
结果:在干预之后,身体成分有显著改善,血脂谱,血糖控制,与非运动组相比,运动组的1RM指数(p<0.05)。与PLB组相比,所有组的AST和ALT水平均降低(p<0.05)。VES+RT组与VES和PLB+RT组之间也存在显著差异(p<0.05)。与非运动组相比,运动组的CTRP-2和CTRP-9水平降低(p<0.05),它们的变化与身体成分有明显的相关性,血脂谱,和血糖控制指数(p<0.05)。
结论:本研究强调了放疗对NAFLD患者各种健康参数的益处。虽然向RT中添加VES会导致转氨酶的减少,它没有提供其他变量的进一步改进。此外,身体成分的增强,血脂谱,血糖控制指数可能与CTRPs水平降低相关。
背景:于2023年12月21日在伊朗临床试验注册中心(IRCT20220601055056N1)中回顾性注册。访问https://irct。behdash.govir/trial/69231。
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) involves excessive liver fat accumulation and is closely linked to oxidative stress, which contributes to liver inflammation and damage. This study aimed to evaluate how interventions such as resistance training (RT) and vitamin E supplementation (VES) can modulate markers of NAFLD and key proteins regulating glucose and lipid metabolism, such as C1Q/TNF-related proteins (CTRPs).
METHODS: Forty participants with NAFLD (mean age: 32.4 ± 8.2 years) were randomly assigned to one of four groups for 12 weeks: placebo (PLB), VES, PLB + RT, and VES + RT. VES was administered at 800 IU/day in a double-blind manner. The RT regimen included eight exercises at 60-80% of one-repetition maximum (1RM), with three sets of 8-12 repetitions, performed three times per week. Pre- and post-intervention assessments included body composition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid profile, glycemic control, CTRP-2, CTRP-9, and 1RM evaluations.
RESULTS: Following the interventions, there was a significant improvement in body composition, lipid profile, glycemic control, and 1RM indices in the exercise groups compared to non-exercise groups (p < 0.05). AST and ALT levels decreased in all groups (p < 0.05) compared to the PLB group. There was also a significant difference between the VES + RT group and both the VES and PLB + RT groups (p < 0.05). CTRP-2 and CTRP-9 levels decreased in the exercise groups compared to non-exercise groups (p < 0.05), and their changes showed a marked correlation with body composition, lipid profile, and glycemic control indices (p < 0.05).
CONCLUSIONS: This study highlights the benefits of RT on various health parameters among NAFLD patients. While adding VES to RT resulted in greater decreases in aminotransferases, it did not provide further improvements in other variables. Additionally, enhancements in body composition, lipid profile, and glycemic control indices were possibly associated with decreased levels of CTRPs.
BACKGROUND: Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20220601055056N1) on December 21, 2023. Access at https://irct.behdasht.gov.ir/trial/69231 .