■肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)是一种慢性,影响全球数百万人的多方面疾病。尽管影响很大,这种疾病的病因仍然知之甚少,症状异质性对诊断和治疗提出了挑战。关节过度活动,常见于高流动性Ehlers-Danlos综合征(hEDS),已在ME/CFS患者中观察到,但其在该人群中的患病率和临床意义未得到很好的表征。
■为了比较使用Beighton评分系统评估的有和没有关节过度活动(JH和JH-)的ME/CFS患者的特征,并探讨JH+ME/CFS患者是否表现出明显的疾病特征,合并症,与健康相关的生活质量(HRQOL)。
■这项研究采用了横截面,您+ME登记处815名参与者的自我报告数据。参与者根据自我评估的Beighton得分分为JH或JH-,并在人口统计中进行比较。合并症,家族史,和症状。使用ShortForm-36RAND调查和Karnofsky绩效状态评估HRQOL。
■15.5%(N=126)的参与者被归类为JH+。JH+参与者更有可能是女性,报告Ehlers-Danlos综合征(EDS),体位性心动过速综合征(POTS),有EDS家族史。他们经历了更糟糕的HRQOL,特别是在身体机能和疼痛方面,和更多的自主神经,神经认知,头痛,gut,gut肌肉骨骼症状.敏感性分析表明,ME/CFS并发JH+和EDS与更严重的症状和更大的功能损害相关。
■患有关节过度活动的ME/CFS患者,特别是那些有EDS的,表现出明显的临床特征,包括更严重的症状和降低的HRQOL。这些发现强调了对具有关节过度活动的ME/CFS患者进行全面临床评估的必要性。了解这些关系可以帮助进行子组识别,改善诊断,并告知有针对性的治疗方法。需要进一步的研究来探索这些关联及其对临床实践的影响。
UNASSIGNED: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally. Despite its significant impact, the disease\'s etiology remains poorly understood, and symptom heterogeneity poses challenges for diagnosis and treatment. Joint hypermobility, commonly seen in hypermobile Ehlers-Danlos Syndrome (hEDS), has been observed in ME/CFS patients but its prevalence and clinical significance within this population are not well-characterized.
UNASSIGNED: To compare the characteristics of ME/CFS patients with and without joint hypermobility (JH+ and JH-) as assessed using the Beighton scoring system, and to explore whether JH+ ME/CFS patients exhibit distinct disease characteristics, comorbidities, and health-related quality of life (HRQOL).
UNASSIGNED: The study used cross-sectional, self-reported data from 815 participants of the You + ME Registry. Participants were categorized as JH+ or JH- based on self-assessed Beighton scores and compared across demographics, comorbidities, family history, and symptoms. HRQOL was assessed using the Short Form-36 RAND survey and Karnofsky Performance Status.
UNASSIGNED: 15.5% (N = 126) of participants were classified as JH+. JH+ participants were more likely to be female, report Ehlers-Danlos Syndrome (EDS), Postural Orthostatic Tachycardia Syndrome (POTS), and a family history of EDS. They experienced worse HRQOL, particularly in physical functioning and pain, and a higher number of autonomic, neurocognitive, headache, gut, and musculoskeletal symptoms. Sensitivity analysis suggested that ME/CFS with concurrent JH+ and EDS was associated with more severe symptoms and greater functional impairment.
UNASSIGNED: ME/CFS patients with joint hypermobility, particularly those with EDS, demonstrate distinct clinical characteristics, including more severe symptomatology and reduced HRQOL. These findings highlight the need for comprehensive clinical assessments of ME/CFS patients with joint hypermobility. Understanding these relationships could aid in subgroup identification, improving diagnosis, and informing targeted therapeutic approaches. Further research is warranted to explore these associations and their implications for clinical practice.