Abstract：
BACKGROUND: Functional Neurological Disorder (FND) is associated with anxiety and depression, and perhaps with joint hypermobility, which is itself associated with anxiety and depression. We conducted a survey to explore the relationship between these.
METHODS: An online survey of people with FND was conducted, with participants asked to nominate healthy controls from their social group to join. Participants were asked about their anxiety (measured with GAD7), depression (measured with PHQ9) and joint hypermobility (measured with 5PQ). A regression analysis was conducted using a general linear model.
RESULTS: 215 people with FND and 22 people without FND were included in the analysis. GAD7, PHQ9 and hypermobility scores were all higher in the group with FND, with 74% of people with FND meeting the common cut-off for a diagnosis of joint hypermobility syndrome, as compared with 45% of those without FND. Anxiety, depression and joint hypermobility scores all predicted FND status, with joint hypermobility the strongest. Hypermobility moderated the effect of anxiety, with the effect being stronger at lower levels of anxiety.
CONCLUSIONS: While anxiety, depression and hypermobility symptoms each appear to contribute to FND, the role of anxiety is moderated by hypermobility, particularly when anxiety is lower.
METHODS: An online survey of people with FND was conducted, with participants asked to nominate healthy controls from their social group to join. Participants were asked about their anxiety (measured with GAD7), depression (measured with PHQ9) and joint hypermobility (measured with 5PQ). A regression analysis was conducted using a general linear model.
RESULTS: 215 people with FND and 22 people without FND were included in the analysis. GAD7, PHQ9 and hypermobility scores were all higher in the group with FND, with 74% of people with FND meeting the common cut-off for a diagnosis of joint hypermobility syndrome, as compared with 45% of those without FND. Anxiety, depression and joint hypermobility scores all predicted FND status, with joint hypermobility the strongest. Hypermobility moderated the effect of anxiety, with the effect being stronger at lower levels of anxiety.
CONCLUSIONS: While anxiety, depression and hypermobility symptoms each appear to contribute to FND, the role of anxiety is moderated by hypermobility, particularly when anxiety is lower.
摘要：
背景：功能性神经障碍（FND）与焦虑和抑郁有关，也许是关节过度活动，这本身与焦虑和抑郁有关。我们进行了一项调查，以探讨两者之间的关系。
方法：对FND患者进行了在线调查，参与者被要求从他们的社会群体中提名健康对照加入。参与者被问及他们的焦虑(用GAD7测量)，抑郁（用PHQ9测量）和关节过度活动（用5PQ测量）。使用一般线性模型进行回归分析。
结果：215名FND患者和22名无FND患者被纳入分析。FND组的GAD7、PHQ9和运动过度评分均较高,74%的FND患者符合关节过度活动综合征的诊断标准，与没有FND的人相比，这一比例为45%。焦虑,抑郁和关节过度活动评分都是预测的FND状态，关节过度活动最强。过度活动减轻了焦虑的影响，在较低的焦虑水平下效果更强。
结论：虽然焦虑，抑郁和过度活动症状似乎都会导致FND，焦虑的作用是由过度活动调节的，特别是当焦虑较低时。
方法：对FND患者进行了在线调查，参与者被要求从他们的社会群体中提名健康对照加入。参与者被问及他们的焦虑(用GAD7测量)，抑郁（用PHQ9测量）和关节过度活动（用5PQ测量）。使用一般线性模型进行回归分析。
结果：215名FND患者和22名无FND患者被纳入分析。FND组的GAD7、PHQ9和运动过度评分均较高,74%的FND患者符合关节过度活动综合征的诊断标准，与没有FND的人相比，这一比例为45%。焦虑,抑郁和关节过度活动评分都是预测的FND状态，关节过度活动最强。过度活动减轻了焦虑的影响，在较低的焦虑水平下效果更强。
结论：虽然焦虑，抑郁和过度活动症状似乎都会导致FND，焦虑的作用是由过度活动调节的，特别是当焦虑较低时。
