背景:超重/肥胖和缺铁在育龄妇女(WRA)中非常普遍,影响妇女的健康。肥胖是营养缺乏的危险因素,但其与铁缺乏的关系尚不清楚。
目的:确定肥胖与WRA中铁状态和铁缺乏患病率的标志物之间的关系。
方法:这项横断面研究分析了国家饮食和营养调查(NDNS,2008-2019)数据,重点关注18-49岁BMI≥18.5kg/m2的女性。贫血的患病率,缺铁性贫血(IDA),和铁缺乏(ID)进行分析。针对C-反应蛋白调节铁蛋白。在高和低BMI中评估铁状态,腰围(WC),腰围到身高(WHtR),腰臀比(WHR)。Chi2,线性和逻辑回归进行校正协变量。
结果:在1,098个WRA中,496正常体重和602超重/肥胖,患病率为:贫血9.2%和IDA6.8%.贫血在WHtR和WHR较高的人群中更为普遍(11.9%vs5.9%和16.7%vs6.5%,两者p<0.001)。WRA增加WC,WHtR,和WHR的IDA患病率高于肥胖较低的人群。(8.5%对4.3%,p=0.005;9.4%对3.3%,p<0.001;12.1%对4.9%,p<0.001)。ID患病率分别为49.7%(铁蛋白截止值30μg/L)和19.6%(铁蛋白截止值15μg/L),不同肥胖组的发病率相似。由可溶性转铁蛋白受体(sTfR)定义的ID患病率在WHR增加的女性中更高(p=0.001)。按sTfR分类的较高WHR预测ID(aOR2.104,p=0.004),和WHtR和WHR预测贫血和IDA(贫血:WHtRaOR2.006p=0.036;WHRaOR4.489p<0.001;IDA:WHtR:aOR2.942,p=0.012;WHRaOR4.142,p<0.001)。
结论:英国至少有五分之一的WRA缺铁,强调需要修改现行政策。较大的中枢肥胖与铁状态受损和贫血的发展密切相关。IDA,和ID。
BACKGROUND: Overweight/obesity and iron deficiency are highly prevalent in women of reproductive age (WRA), impacting on women\'s health. Obesity is a risk factor for nutritional deficiencies but its association with iron deficiency is unclear.
OBJECTIVE: To determine the association between adiposity and markers of iron status and iron deficiency prevalence in WRA.
METHODS: This cross-sectional study analyzed the National Diet and Nutrition Survey (NDNS, 2008-2019) data, focusing on women aged 18-49y with BMI ≥18.5 kg/m2. Prevalence of anemia, Iron Deficiency Anemia (IDA), and Iron Deficiency (ID) were analyzed. Ferritin was adjusted for C-reactive protein. Iron status was assessed across high and low BMI, waist circumference (WC), waist-to-height (WHtR), and waist-to-hip ratio (WHR). Chi2, linear and logistic regression were performed adjusting for covariates.
RESULTS: Among 1,098 WRA, 496 normal weight and 602 overweight/obesity, prevalence rates were: anemia 9.2% and IDA 6.8%. Anemia was more prevalent in those with higher WHtR and WHR (11.9% vs 5.9% and 16.7% vs 6.5%, both p<0.001). WRA with increased WC, WHtR, and WHR had higher IDA prevalence than those with lower adiposity. (8.5% vs 4.3%, p=0.005; 9.4% vs 3.3%, p<0.001; 12.1% vs 4.9%, p<0.001). ID prevalence was 49.7% (ferritin cut-off 30 μg/L) and 19.6% (ferritin cut-off 15 μg/L), showing similar rates across adiposity groups. ID prevalence defined by soluble transferrin receptor (sTfR) was higher in women with increased WHR (p=0.001). Higher WHR predicted ID categorized by sTfR (aOR 2.104, p=0.004), and WHtR and WHR predicted anemia and IDA (anemia: WHtR aOR 2.006 p=0.036; WHR aOR 4.489 p<0.001; IDA: WHtR: aOR 2.942, p=0.012; WHR aOR 4.142, p<0.001).
CONCLUSIONS: At least one in five WRA in the UK are iron deficient, highlighting the need to revise current policies. Greater central adiposity was strongly associated with impaired iron status and the development of anemia, IDA, and ID.