目的:本研究的目的是调查HEV疫苗接种意向,它的决定因素,和育龄妇女的总体影响机制。
方法:当前的研究是横断面的,于2023年6月25日至2023年9月25日在南京在线进行,中国。构建Logistic回归模型以识别意图相关背景因素。将技术接受模型(TAM)和计划行为理论(TPB)整合并扩展为TAM-TPB模型,以使用结构方程模型进一步研究该人群中HEV疫苗接种意愿的决定因素和总体影响机制。
结果:总共423名符合条件的参与者被纳入本研究。高的一般HEV知识与接受HEV疫苗的意愿增加独立相关(OR=1.97,95%CI:1.11-3.58,P=0.023)。理论TAM-TPB模型中提出的所有假设都得到了支持,具有明显的易用性,感知有用性,态度,主观规范,和感知行为控制对HEV疫苗接种意向有正向影响(所有P值<0.05),而感知风险(P=0.003)与HEV疫苗接种意向呈负相关。该模型实现了可接受的拟合,HEV疫苗接种意向的总解释方差高达86.20%。此外,未观察到显著的普通方法偏倚.
结论:这是第一个基于理论的研究,探索HEV疫苗接种意向,它的决定因素,育龄妇女的总体影响机制。本研究结果对于提高育龄女性对HEV疫苗接种意向的认识具有重要意义。
OBJECTIVE: The purpose of this study was to investigate the HEV vaccination intention, its determinants, and overall influence mechanisms among childbearing-age women.
METHODS: The current study was cross-sectional and conducted online from June 25, 2023 to September 25, 2023 in Nanjing, China. Logistic regression models were constructed to identify the intention-associated background factors. Technology Acceptance Model (TAM) and Theory of Planned Behavior (TPB) were integrated and expanded as TAM-TPB model to further investigate the determinants and overall influence mechanism of HEV vaccination intention among this population using structural equation modeling.
RESULTS: A total of 423 eligible participants were included in this study. High general HEV knowledge was independently associated with an increased intention to get HEV vaccination (OR = 1.97, 95 % CI: 1.11-3.58, P = 0.023). All the hypotheses proposed in the theoretical TAM-TPB model were supported, with perceived ease of use, perceived usefulness, attitude, subjective norm, and perceived behavioral control positively affecting the intention of HEV vaccination (all P values <0.05), while perceived risk (P = 0.003) exhibited an inverse association with HEV vaccination intention. The model achieved an acceptable fit, and the total explained variance of HEV vaccination intention was as high as 86.20 %. Moreover, no significant common method bias was observed.
CONCLUSIONS: This is the first theory-based study that explored the HEV vaccination intention, its determinants, and overall influence mechanism among childbearing-age women. The results of the current study are of great importance for improving the understanding of the HEV vaccination intention among females of childbearing age.