目标:尽管以前的研究已经描述了现象学诊断,他们缺乏对就诊运动障碍(MD)服务的患者的病因谱的描述。在这里,我们对MD现象学进行了分类,并描述了每种现象学在接受三级护理运动障碍服务的患者中的病因学分布。
方法:收集的信息包括人口统计学特征(发病年龄,介绍时的年龄,性别,陈述前的疾病持续时间),主要的MD现象学[如帕金森病,肌张力障碍,共济失调,震颤,舞蹈病,弹道,肌阵鸣,Tics,刻板印象,不宁腿综合征(RLS)及其他],诊断评估和发现病因。
结果:这项观察性研究包括1140例MD患者,历时5年。发病年龄中位数(IQR)为49(35-60)岁,就诊年龄为54(40-65)岁,中位病程为36(18-72)个月。近三分之二的患者是男性(M:F=731:409)。帕金森病(n=494,43.3%)是最常见的MD现象学观察,其次是肌张力障碍(n=219,19.2%),共济失调(n=125,11%),震颤(n=118,10.4%),肌阵鸣(n=73,6.4%),舞蹈病(n=40,3.5%),痉挛(n=22,1.9%),Tics(n=8,0.7%),和RLS(n=8,0.7%)。将33例(2.9%)患者分组在其他MD下。总的来说,神经退行性疾病(57.4%)是MDs的最常见原因.帕金森病,遗传性肌张力障碍,特发性震颤,遗传性共济失调,面肌痉挛,亨廷顿病是帕金森病最常见的病因,肌张力障碍,震颤,共济失调,肌阵鸣,和舞蹈症,分别。
结论:帕金森病是在MD患者中观察到的最常见的现象学,接着是肌张力障碍,共济失调和震颤。神经退行性疾病是最常见的病因。
OBJECTIVE: Although previous studies have described phenomenological diagnoses, they lacked description of aetiological spectrum in patients visiting movement disorders (MD) service. Herein, we classify the MD phenomenology and describe aetiology wise distribution of each phenomenology in patients visiting a tertiary care movement disorders service.
METHODS: Collected information included demographic profile (age of onset, age at presentation, gender, duration of illness before presentation), predominant MD phenomenology [such as parkinsonism,
dystonia, ataxia, tremor, chorea, ballism, myoclonus, tics, stereotypy, restless legs syndrome (RLS) and others], diagnostic evaluations and detected aetiology.
RESULTS: This observational study included 1140 MD patients over a span of 5 years. The median (IQR) age of onset was 49 (35-60) years and age at presentation was 54 (40-65) years, with median duration of illness being 36 (18-72) months. Nearly two-third of patients were males (M:F=731:409). Parkinsonism (n=494, 43.3 %) was the most common MD phenomenology observed, followed by
dystonia (n=219, 19.2 %), ataxia (n=125, 11 %), tremor (n=118, 10.4 %), myoclonus (n=73, 6.4 %), chorea (n=40, 3.5 %), spasticity (n=22, 1.9 %), tics (n=8, 0.7 %), and RLS (n=8, 0.7 %). Thirty-three (2.9 %) patients were grouped under miscellaneous MDs. Overall, neurodegenerative disorders (57.4 %) were the most common cause of MDs. Parkinson\'s disease, genetic
dystonia, essential tremor, genetic ataxias, hemifacial spasm, and Huntington\'s disease were the most common aetiologies for parkinsonism,
dystonia, tremor, ataxia, myoclonus, and chorea, respectively.
CONCLUSIONS: Parkinsonism was the most common phenomenology observed in MD patients, and was followed by
dystonia, ataxia and tremor. Neurodegenerative disorders were the most common aetiology detected.