慢性牙周炎是一种多因素疾病,会导致牙齿周围的支持组织发炎并被破坏,这进一步导致牙齿活动性和最终的牙齿脱落。碱性磷酸酶(ALP),参与骨吸收和牙龈炎症,是一种重要的生物标志物。本研究的目的是比较血清,龈沟液(GCF),非手术牙周治疗前后慢性牙周炎患者的唾液ALP水平。
■根据临床和影像学检查,72名参与者分为两组:I组(健康个体)和II组(慢性牙周炎患者)。所有处于无菌状态的患者都有血清,GCF,和未经刺激的唾液,然后使用ALP试剂盒测试样品的ALP水平。
■唾液的差异,血清,对照组(23.44±4.76、58.88±8.29和776.76±121.91)与研究组(105.66±16.33、102.38±4.43和1,825.77±275.12)之间的GCFALP水平差异有统计学意义,P<0.001。唾液的差异,血清,GCFALP水平从基线(105.66±16.33、102.38±4.43和1,825.77±275.12)到术后(49.54±5.69、83.46±4.22和1,148.38±129.01)有统计学意义,P<0.001。结果表明,慢性牙周炎患者的血清水平相当高,GCF,和唾液ALP比健康个体。
■唾液和GCFALP因此可以用作牙周疾病中的关键炎症诊断生物标志物。
UNASSIGNED: Chronic periodontitis is a multifactorial disease that causes the supporting tissues around the teeth to become inflamed and destroyed, which further causes tooth mobility and eventual tooth loss. The enzyme alkaline phosphatase (ALP), which is involved in bone resorption and gingival inflammation, is an important biomarker. The current study\'s objective is to compare the serum, gingival crevicular fluid (GCF), and salivary levels of ALP in individuals with chronic periodontitis before and after nonsurgical periodontal therapy.
UNASSIGNED: On the basis of clinical and radiographic examinations, 72 participants were split into two groups: Group I (healthy individuals) and Group II (chronic periodontitis patients). All patients who were in an aseptic condition had their serum, GCF, and unstimulated saliva taken, and samples were then tested for ALP levels using ALP kit.
UNASSIGNED: The difference in salivary, serum, and GCF ALP levels between the control group (23.44 ± 4.76, 58.88 ± 8.29, and 776.76 ± 121.91) and the study group (105.66 ± 16.33, 102.38 ± 4.43, and 1,825.77 ± 275.12) was found to be statistically significant with P < 0.001. The difference in salivary, serum, and GCF ALP levels from baseline (105.66 ± 16.33, 102.38 ± 4.43, and 1,825.77 ± 275.12) to postoperative (49.54 ± 5.69, 83.46 ± 4.22, and 1,148.38 ± 129.01) was found to be statistically significant with P < 0.001. The results demonstrated that patients with chronic periodontitis have considerably higher levels of serum, GCF, and salivary ALP than healthy individuals.
UNASSIGNED: Salivary and GCF ALP can thus be used as a key inflammatory diagnostic biomarker in periodontal diseases.