■过氧化物酶(PRDX)蛋白家族参与癌细胞的侵袭和转移,但其在肺癌中的预后价值仍然难以捉摸。
■在本报告中,我们通过Kaplan-Meier绘图仪(KM绘图仪)数据库获取每个个体PRDXmRNA表达的总生存期(OS),其中更新的基因表达数据和生存信息包括总共1,926名肺癌患者。
■我们的结果表明,PRDX1和PRDX2mRNA的表达与所有肺癌患者的OS改善有关,尤其是在肺腺癌患者中。而在所有肺癌患者中,PRDX5和PRDX6mRNA表达与不良OS相关。此外,根据吸烟状况,PRDXs在不同临床病理特征中的预后价值,病理等级,临床分期,肺癌患者的化疗治疗在KM绘图仪数据库中通过多变量cox回归分析进一步评估。
■我们的发现将阐明PRDX在肺癌中的预后作用,并可能促进PRDX靶向抑制剂治疗肺癌的发展。
UNASSIGNED: The peroxiredoxin (
PRDX) protein family is involved in cancer cell invasion and metastasis, but its prognostic value in lung cancer remain elusive.
UNASSIGNED: In this report, we accessed the overall survival (OS) of each individual
PRDX mRNA expression through the Kaplan-Meier plotter (KM plotter) database, in which updated gene expression data and survival information include a total of 1,926 lung cancer patients.
UNASSIGNED: Our results indicated that PRDX1 and PRDX2 mRNA expressions were associated with improved OS in all lung cancer patients especially in lung adenocarcinoma patients, whereas PRDX5 and PRDX6 mRNA expressions were associated with poor OS in all lung cancer patients. In addition, the prognostic value of PRDXs in the different clinicopathological features according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of lung cancer patients was further assessed in the KM plotter database by the multivariate cox regression analysis.
UNASSIGNED: Our finding will elucidate the prognostic role of PRDXs in lung cancer and might promote development of
PRDX-targeted inhibitors for the treatment of lung cancer.