目的:本研究旨在提供对继发性肥厚性骨关节病(HOA)病例的详细评估,并探索对中世纪意大利农村地区疾病的存在和后果的见解。
方法:从中世纪的PievediPava(锡耶纳,意大利)。
方法:宏观和放射学(X射线,进行CT)分析。
结果:在这个人的长骨的骨干和干phy端区域对称广泛的骨膜新骨形成;下肢比上肢受到更广泛和更严重的影响,与近端相比,远端的改变更严重。
结论:宏观和放射学特征与继发性HOA的诊断高度一致。
结论:出色的保存状态允许评估很少注意到的HOA骨骼表现,并提供了对中世纪意大利农村生活方面的见解。
结论:分子分析不能成功测序结核的aDNA,因此,继发性HOA的潜在主要原因,无论是肺还是肺外,在这种情况下仍然晦涩难懂。
■建议定期重新访问来自骨考古收集的数据,以确定进一步的HOA病例,同时进一步调查已知病例,寻找潜在的原发疾病。
OBJECTIVE: This study aims to provide a detailed evaluation of a case of secondary hypertrophic osteoarthropathy (HOA) and to explore insights into the presence and consequences of disease in medieval rural Italy.
METHODS: The skeleton of a male (US 4405) with an estimated age at death of 51-69 years excavated from the medieval rural site of Pieve di Pava (Siena, Italy).
METHODS: Macroscopic and radiological (x-ray, CT) analyses were performed.
RESULTS: Symmetrical extensive periosteal new bone formation on the diaphyseal and metaphyseal regions of this individual\'s long bones; the lower limbs were more extensively and severely affected than the upper limbs and the distal segments were more severely altered in comparison to the proximal ones.
CONCLUSIONS: The macroscopic and radiological features are highly consistent with a diagnosis of secondary HOA.
CONCLUSIONS: The excellent state of preservation allowed the evaluation of rarely noted skeletal manifestations of HOA and provided insight into aspects of rural life in medieval Italy.
CONCLUSIONS: Molecular analysis was not successful in sequencing the aDNA of tuberculosis, therefore the underlying primary cause of secondary HOA, whether pulmonary or extrapulmonary, remains obscure in this case.
UNASSIGNED: It is advisable to regularly revisit the data available from osteoarchaeological collections in order to identify further cases of HOA, along with to further investigate the known cases to search for the underlying primary disease.