数字俱乐部和肥厚性骨关节病(HOA)是长期存在的临床实体,但是它们的流行还没有被综合。我们旨在估计有现有医疗条件的人群中数字俱乐部和HOA的患病率。我们全面搜索了PubMed,Embase,和WebofScience选择针对HOA或数字俱乐部的研究,并在2021年3月23日之前发布。患病率的汇总估计是通过随机效应荟萃分析和叙事综合得出的。审查协议已经在PROSPERO注册,CRD42021243934。3973条记录中,我们纳入了142项研究。在成年人中,数字俱乐部的合并患病率为33.4%(95%置信区间[CI],16.6-52.8),31.3%(95%CI,22.4-41.1),27%(95%CI,9.4-49.5),在患有肠道疾病的受试者中,22.8%(95%CI,10.8-37.6),间质性肺病,感染性心内膜炎,和肝脏疾病,分别。在儿童和青少年中,数字俱乐部的合并患病率为29.1%(95%CI,19.4-39.9),23%(95%CI,9.0-41.1),19.5%(95%CI,4.1-42.4),和17.1%(95%CI,9.5-26.5)在患有人类免疫缺陷病毒感染的受试者中,血红蛋白病,囊性纤维化,和肺结核。在患有癌症的成年人中,HOA的合并患病率为10.1%(95%CI,2.0-23.1),5%(95%CI,2.5-8.2)在患有囊性纤维化的儿童和青少年中。总之,不同疾病组的成人和儿童数字俱乐部的患病率不同.全谱HOA主要在患有肝病和癌症的成年人中报道,以及患有囊性纤维化的儿童和青少年。
Digital clubbing and hypertrophic osteoarthropathy (HOA) are long-standing clinical entities, but their prevalence have not been synthesized. We aimed to estimate the prevalence of digital clubbing and HOA in people with existing medical conditions.We comprehensively searched PubMed, Embase, and Web of Science to select studies addressing HOA or digital clubbing and published through March 23, 2021. Summary estimates of the prevalence were derived through random-effects meta-analysis and narrative synthesis. The
review protocol has been registered with PROSPERO, CRD42021243934.Of 3973 records, we included 142 studies. In adults, the pooled prevalence of digital clubbing was 33.4% (95% confidence interval [CI], 16.6-52.8), 31.3% (95% CI, 22.4-41.1), 27% (95% CI, 9.4-49.5), and 22.8% (95% CI, 10.8-37.6) in subjects with intestinal diseases, interstitial lung diseases, infective endocarditis, and hepatic diseases, respectively. In children and adolescents, the pooled prevalence of digital clubbing was 29.1% (95% CI, 19.4-39.9), 23% (95% CI, 9.0-41.1), 19.5% (95% CI, 4.1-42.4), and 17.1% (95% CI, 9.5-26.5) in subjects with human immunodeficiency virus infection, hemoglobinopathies, cystic fibrosis, and tuberculosis. The pooled prevalence of HOA was 10.1% (95% CI, 2.0-23.1) in adults with cancers, and 5% (95% CI, 2.5-8.2) in children and adolescents with cystic fibrosis.In conclusion, the prevalence of digital clubbing varied across disease groups in both adults and children. Full-spectrum HOA was mostly reported in adults with liver disease and cancers, and in children and adolescents with cystic fibrosis.