有限的证据表明邻苯二甲酸酯暴露与生物衰老之间存在关系。这项研究调查了邻苯二甲酸酯暴露与生物衰老之间的关系,关注炎症的中介作用以及与膳食营养素摄入的相互作用。数据来自一项全国性的横断面调查,包括12,994名18岁及以上的参与者。在斑点尿液样品中检测到八种邻苯二甲酸酯代谢物。使用Klemera-Doubal方法-生物年龄(KDM-BA)加速度评估生物衰老,表型年龄(PA)加速度,和体内平衡失调(HD)。全身免疫-炎症指数(SII)评价全身炎症。使用线性回归评估邻苯二甲酸盐暴露与生物衰老之间的个体和组合关联,加权分位数和(WQS)回归,和分位数g计算(qgcomp)。参与者的平均年龄为47岁,50.7%的男性和44.8%的非西班牙裔白人。大多数邻苯二甲酸酯代谢物与KDM-BA加速度呈正相关(β=0.306-0.584),PA加速度(β=0.081-0.281),和HD(β=0.016-0.026)。亚组分析表明,男性,老年人,非西班牙裔白人是特别敏感的人群。WQS回归和qgcomp分析一致表明混合邻苯二甲酸盐暴露与HD之间存在正相关,强调MEHHP是最重要的代谢产物。中介分析显示,炎症部分介导了邻苯二甲酸酯代谢产物与生物衰老之间的关联。在特定的邻苯二甲酸酯代谢产物和膳食营养素(类胡萝卜素,维生素A,B1,B2,B6,B12,烟酸,和硒)摄入量。这些结果表明,邻苯二甲酸盐暴露与生物衰老之间的关联是由炎症介导的,营养摄入减轻了这种影响。
Limited evidence has suggested a relationship between phthalate exposure and biological aging. This study investigated the association between phthalate exposure and biological aging, focusing on the mediating role of inflammation and the interaction with dietary nutrient intake. Data were analyzed from a nationwide cross-sectional survey comprising 12,994 participants aged 18 and above. Eight phthalate metabolites were detected in spot urine samples. Biological aging was assessed using the Klemera-Doubal method-biological age (KDM-BA) acceleration, phenotypic age (PA) acceleration, and homeostatic dysregulation (HD). The systemic immune-inflammation index (SII) evaluated systemic inflammation. The individual and combined associations between phthalate exposure and biological aging were assessed using linear regression, weighted quantile sum (WQS) regression, and quantile g-computation (qgcomp). The participants had a mean age of 47 years, with 50.7 % male and 44.8 % non-Hispanic white. Most phthalate metabolites were positively correlated with KDM-BA acceleration (β = 0.306-0.584), PA acceleration (β = 0.081-0.281), and HD (β = 0.016-0.026). Subgroup analysis indicated that men, older individuals, and non-Hispanic whites are particularly sensitive populations. WQS regression and qgcomp analyses consistently indicated a positive association between mixed phthalate exposure and HD, highlighting MEHHP as the most significant contributing metabolite. Mediation analyses showed inflammation partially mediated the association between phthalate metabolites and biological aging. Significant interactions regarding biological aging were found between specific phthalate metabolites and dietary
nutrients (carotenoids, vitamins A, B1, B2, B6, B12, niacin, and selenium) intake. These findings indicated that the association between phthalate exposure and biological aging was mediated by inflammation, with nutrient intake mitigating this effect.