■轻链(AL)淀粉样变性是系统性淀粉样变性最普遍的亚型,包括一组罕见的疾病。这里,我们评估了AL淀粉样变性的科学前景,以调查研究趋势并确定该领域的热点。
■在过去20年中发表的关于AL淀粉样变性的相关研究从WebofScienceCoreCollection检索。2005年至2024年的出版物进行了文献计量分析,利用包括CiteSpace在内的工具,VOSviewer,RStudio和MSExcel分析和可视化年度出版物趋势,共现模式,国家之间的合作网络,组织,和作者。还检查了突发关键词和参考文献,以获得研究历史,和新兴热点。
■文献计量分析包括2005年至2024年之间发表的2864篇文章。最有成效的杂志是淀粉样蛋白折叠疾病杂志。美国,以及几个发达国家,成为国际AL淀粉样变性研究的主导力量。“AL淀粉样变性”和“心脏淀粉样变性”是过去二十年来的主要热点,和“生物标志物,心脏淀粉样变性,“和”治疗“将是未来的趋势。
■该文献计量分析使用文献计量软件检查了过去二十年来AL淀粉样变性的研究进展。该领域的最新研究主要集中在两个主要领域:AL淀粉样变性的临床诊断和治疗,以及心脏淀粉样变性.重点是理解免疫球蛋白轻链聚集和沉积以减轻器官参与的潜在机制。
UNASSIGNED: Light chain (AL) amyloidosis stands as the most prevalent subtype of systemic amyloidosis, encompassing a group of rare diseases. Here, we evaluated the scientific landscape of AL amyloidosis to investigate research trends and identify hotspots within the field.
UNASSIGNED: Relevant studies on AL amyloidosis published over the past two decades were retrieved from the Web of Science Core Collection. The publications between 2005 and 2024 were subjected to bibliometric analyses, leveraging tools including CiteSpace, VOSviewer, RStudio and MS Excel to analyse and visualize the annual publication trend, co-occurrence patterns, collaborative networks among countries, organizations, and authors. Burst keywords and references were also examined to obtain the research history, and emerging hotspots.
UNASSIGNED: The bibliometric analysis included 2,864 articles published between 2005 and 2024. The most productive journal is Amyloid-Journal of Protein Folding Disorders. The United States, along with several developed nations, emerges as a dominant force in international AL amyloidosis research. \"AL amyloidosis\" and \"cardiac amyloidosis\" were the primary hotspots over the past two decades, and \"Biomarkers,\" \"Cardiac amyloidosis,\" and \"treatment\" would be future trends.
UNASSIGNED: This bibliometric analysis examined the research developments in AL amyloidosis over the past two decades using bibliometric software. Recent research in this field primarily focuses on two main areas: clinical diagnosis and treatment of AL amyloidosis, as well as cardiac amyloidosis. Emphasis is placed on understanding the mechanisms underlying immunoglobulin light chain aggregation and deposition to mitigate organ involvement.