■淀粉样蛋白轻链(AL)淀粉样变性是最常见的全身性淀粉样变性。这项范围审查的目的是绘制有关中国AL淀粉样变性诊断的可用文献。
■从2000年1月1日至2021年9月15日筛选了与AL淀粉样变性诊断有关的已发表学术论文。包括疑似AL淀粉样变性的中国患者。根据研究是否提供诊断准确性数据,将纳入的研究分为准确性研究和描述性研究。综合了纳入研究报告的诊断方法信息。
■最终范围审查包括43篇文章,其中31项属于描述性研究,12项具有诊断准确性信息。尽管在中国AL淀粉样变性患者中心脏受累位居第二,心脏活检是罕见的。接下来,我们发现轻链分类和单克隆(M-)蛋白鉴定是诊断中国AL淀粉样变性的重要方法。此外,一些联合测试(例如免疫组织化学和血清游离轻链,免疫组织化学和免疫固定电泳,和血清游离轻链和免疫固定电泳)可以增加诊断的敏感性。最后,几种辅助方法(例如成像,N-末端前激素BNP,和脑钠肽测试)对于AL淀粉样变性诊断很重要。
■本范围综述详细介绍了最近发表的中国AL淀粉样变性诊断研究的特征和结果。在中国,活检是诊断AL淀粉样变性的最重要方法。此外,联合试验和一些辅助方法在诊断中发挥了重要作用。需要进一步研究以确定症状发作后可接受且可行的诊断算法。注册:INPLASY2022100096KEYMESSAGES本范围审查详细介绍了最近发表的诊断淀粉样轻链(AL)淀粉样变性的研究的特征和结果。在中国,活检是诊断AL淀粉样变性的最重要方法。联合检查和一些辅助方法在诊断中起着至关重要的作用。
Amyloid light chain (AL) amyloidosis is the most common systemic amyloidosis. The objective of this scoping
review was to map the available literature on the diagnosis of AL amyloidosis in China.
The published academic papers related to the diagnosis of AL amyloidosis were screened from 1 January 2000 to 15 September 2021. Chinese patients who have suspected AL amyloidosis were included. The included studies were categorized into accuracy studies and descriptive studies based on if the studies supplied the diagnostic accuracy data or not. The information on the diagnostic methods reported by included studies was synthesized.
Forty-three articles were included for the final scoping
review, with 31 belonging to descriptive studies and 12 having information on diagnostic accuracy. Although cardiac involvement was second top in Chinese patients with AL amyloidosis, a cardiac biopsy was rare. Next, we found light chain classification and monoclonal (M-) protein identification were essential methods for the diagnosis of AL amyloidosis in China. In addition, some combined tests (e.g. immunohistochemistry and serum free light chain, immunohistochemistry and immunofixation electrophoresis, and serum free light chain and immunofixation electrophoresis) can increase the sensitivity of the diagnosis. Finally, several adjuvant methods (e.g. Imaging, N-terminal-pro hormone BNP, and brain natriuretic peptide test) were important for AL amyloidosis diagnosis.
This scoping
review details the characteristics and results of the recently published studies on diagnosing AL Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. In addition, combined tests and some adjuvant methods played essential roles in the diagnosis. Further research is required to determine an acceptable and feasible diagnostic algorithm after symptom onset. REGISTRATION: INPLASY2022100096KEY MESSAGESThis scoping
review details the characteristics and results of the recently published studies on diagnosing Amyloid light chain (AL) Amyloidosis in China.Biopsy is the most important method for AL Amyloidosis diagnosis in China.Combined tests and some adjuvant methods played essential roles in the diagnosis.