环肽是由蛋白质来源的或非蛋白质来源的氨基酸之间的酰胺键的环状序列形成的多肽链。与线性肽相比,环肽提供了几个独特的优势,例如增加稳定性,亲和力更强,改进的选择性,减少毒性。环肽已被证明在医学领域具有广阔的应用前景。此外,本文主要阐述了环肽在抗癌中的重要作用,抗炎,抗病毒,通过免疫调节治疗多发性硬化和膜性肾病。为了了解环肽在临床研究和药物应用中的更多有用信息,本文还对目前处于临床试验阶段的环肽和近5年获批上市的环肽类药物进行了综述。环肽在治疗各种疾病方面具有许多优点和巨大潜力,但在环肽的开发过程中仍有许多挑战有待解决。
Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammatory, anti-virus, treatment of multiple sclerosis and membranous nephropathy through immunomodulation. In order to know more useful information about cyclic peptides in clinical research and drug application, this paper also summarizes cyclic peptides currently in the clinical trial stage and cyclic peptide drugs approved for marketing in the recent five years. Cyclic peptides have many advantages and great potential in treating various diseases, but there are still many challenges to be solved in the development process of cyclic peptides.