胰腺衍生的胰岛淀粉样多肽(IAPP)在2型糖尿病(T2D)患者的胰腺和周围聚集和沉积,导致糖尿病并发症。过量的IAPP可以通过自身抗体去除,并且在T2D患者中已经报道了针对IAPP的免疫球蛋白(Ig)G水平升高。然而,其他Ig类是否也受到影响,以及级别是否可以管理,目前尚不清楚。这项事前研究检查了T2D患者针对IAPP寡聚体(IAPPO-IgA)的IgA水平,并评估了基于冲绳的北欧(O-BN)饮食的影响-一种低碳水化合物,高纤维饮食-在饮食3个月后达到这些水平。IAPP,IAPPO-IgA,在基线时收集的n=30名T2D患者的血浆和粪便样本中测量总IgA水平,经过3个月的饮食,和额外4个月的无限制饮食(临床随访)后。3个月后IAPP和IAPPO-IgA水平显著降低,后者在临床随访中也显着减少。血浆IAPP和IAPPO-IgA水平的降低与代谢和炎症标志物的血浆水平的降低相关。因此,遵循O-BN饮食至少3个月足以降低循环IAPP和IAPPO-IgA水平,这可能是管理T2D的主要原因。
Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to diabetic complications. The excess IAPP can be removed by autoantibodies, and increased levels of immunoglobulin (Ig) G against IAPP have been reported in T2D patients. However, whether other Ig classes are also affected and if the levels can be managed is less known. This pre-post study examines
IgA levels against IAPP oligomers (IAPPO-
IgA) in T2D patients and assesses the impact of the Okinawa-based Nordic (O-BN) diet-a low-carbohydrate, high-fiber diet-on these levels after following the diet for 3 months. IAPP, IAPPO-
IgA, and total
IgA levels were measured in plasma and fecal samples from n = 30 T2D patients collected at baseline, after 3 months of diet, and after additional 4 months of unrestricted diets (a clinical follow-up). The IAPP and IAPPO-
IgA levels were significantly lower after 3 months, with the latter also being significantly reduced at the clinical follow-up. The reduction in plasma IAPP and IAPPO-
IgA levels correlated with reductions in plasma levels of metabolic and inflammatory markers. Hence, following the O-BN diet for at least 3 months is sufficient to reduce circulating IAPP and IAPPO-
IgA levels, which may be principal in managing T2D.