■2型单纯疱疹(HSV-2)感染的患病率上升对全球公共卫生提出了越来越大的挑战。全面了解中国的流行病学和负担差异对于将来制定有针对性和有效的干预策略至关重要。
■我们遵循Cochrane和PRISMA指南进行了系统的审查,并包括了在3月31日之前以中英文书目系统出版的出版物,2024.我们合成了不同人群类型的HSV-2血清阳性率数据。我们使用随机效应模型进行荟萃分析,并进行荟萃回归来评估人群特征与血清阳性率之间的关联。
■总的来说,确认了23999篇文章,纳入了报告总体血清阳性率(858项分层测量)的402份出版物(1,203,362名参与者).一般人群(风险较低)中合并HSV-2血清阳性率为7.7%(95%CI:6.8-8.7%)。与普通人群相比,在中等风险人群中,HSV-2患病率的风险较高(14.8%,95%CI:11.0-19.1%),和关键人群(31.7%,95%CI:27.4-36.1%)。女性性工作者(FSW)的HSV-2风险最高(ARR:1.69,95%CI:1.61-1.78)。我们发现东北地区的HSV-2血清阳性率高于其他地区(17.0%,95%CI:4.3-35.6%,ARR:1.38,95%CI:1.26-1.50,华北为参照组)。这突出了人口风险水平和地区的差异。我们还发现,在关键人群(如MSM和HIV不和谐人群)中,中国书目数据库出版物中的HSV-2患病率估计值低于英文数据库。
■HSV-2患病率风险分层存在梯度增加。我们还确定了区域,人口,以及HSV-2负担中出版物语言的年龄差异和异质性。这项研究为未来的HSV-2预防提供了指导,以消除HSV-2感染的差异并减少整体HSV-2负担。
■https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=408108,标识符CRD42023408108。
UNASSIGNED: The rising prevalence of herpes simplex type 2 (HSV-2) infection poses a growing global public health challenge. A comprehensive understanding of its epidemiology and burden disparities in China is crucial for informing targeted and effective intervention strategies in the future.
UNASSIGNED: We followed Cochrane and PRISMA guidelines for a systematic review and included publications published in Chinese and English bibliographic systems until March 31st, 2024. We synthesized HSV-2 seroprevalence data across different population types. We used random-effects models for meta-analyses and conducted meta-regression to assess the association between population characteristics and seroprevalence.
UNASSIGNED: Overall, 23,999 articles were identified, and 402 publications (1,203,362 participants) that reported the overall seroprevalence rates (858 stratified measures) were included. Pooled HSV-2 seroprevalence among the general population (lower risk) was 7.7% (95% CI: 6.8-8.7%). Compared to the general population, there is a higher risk of HSV-2 prevalence among intermediate-risk populations (14.8%, 95% CI: 11.0-19.1%), and key populations (31.7%, 95% CI: 27.4-36.1%). Female sexual workers (FSWs) have the highest HSV-2 risk (ARR:1.69, 95% CI: 1.61-1.78). We found northeastern regions had a higher HSV-2 seroprevalence than other regions (17.0%, 95% CI: 4.3-35.6%, ARR: 1.38, 95% CI: 1.26-1.50, Northern China as the reference group). This highlighted the disparity by population risk levels and regions. We also found lower HSV-2 prevalence estimates in publications in Chinese bibliographic databases than those in English databases among key populations (such as MSM and HIV-discordant populations).
UNASSIGNED: There is a gradient increase in HSV-2 prevalence risk stratification. We also identified region, population, and age disparities and heterogeneities by publication language in the HSV-2 burden. This study provides guidance for future HSV-2 prevention to eliminate disparities of HSV-2 infection and reduce overall HSV-2 burden.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=408108, identifier CRD42023408108.