PDF(Pubmed)
Abstract：
From established latency, human herpes virus type 2 (HSV-2) frequently reactivates into the genital tract, resulting in symptomatic ulcers or subclinical shedding. Tissue-resident memory (TRM) CD8+ T cells that accumulate and persist in the genital skin at the local site of recrudescence are the \"first responders\" to viral reactivation, performing immunosurveillance and containment and aborting the ability of the virus to induce clinical lesions. This review describes the unique spatiotemporal characteristics, transcriptional signatures, and noncatalytic effector functions of TRM CD8+ T cells in the tissue context of human HSV-2 infection. We highlight recent insights into the intricate overlaps between intrinsic resistance, innate defense, and adaptive immunity in the tissue microenvironment and discuss how rapid virus-host dynamics at the skin and mucosal level influence clinical outcomes of genital herpes diseases.
摘要：
从既定的延迟，人类疱疹病毒2型（HSV-2）经常重新激活到生殖道，导致有症状的溃疡或亚临床脱落。组织驻留记忆（TRM）CD8+T细胞在生殖器皮肤上积聚并持续在复发的局部部位是病毒再激活的“第一反应者”，进行免疫监视和遏制，并中止病毒诱导临床病变的能力。这篇综述描述了独特的时空特征，转录签名，在人HSV-2感染的组织背景下，TRMCD8+T细胞的非催化效应功能。我们强调了对内在阻力之间复杂重叠的最新见解，天生的防御，以及组织微环境中的适应性免疫，并讨论皮肤和粘膜水平的快速病毒宿主动力学如何影响生殖器疱疹疾病的临床结果。
