丁型肝炎病毒(HDV),乙型肝炎病毒的卫星病毒,加重受影响个体的肝损伤。建议在HBsAg阳性患者中筛查HDV抗体,但血清学检测的诊断准确性仍不确定.这篇综述旨在评估血清学测试对HDV的诊断准确性。我们搜索了PubMed,WebofScience,Cochrane中央控制试验登记册,Scopus等.进行相关研究。包括测量血清学HDV测试对作为参考标准的PCR的敏感性和特异性的研究。计算每种测试方法和血清标记物的合并敏感性和特异性。该综述包括6项研究和11个研究组,评估建筑师免疫测定,EIA,ELISA,QMAC,RIA,和针对抗HDVIgG的蛋白质印迹测试方法,总抗HDV和抗HDVIgM。抗HDVIgG的敏感性,总抗HDV和抗HDVIgM,测试为97.4%,51.9%,62.0%,分别,特异性为95.3%,80.0%,和85.0%。我们的发现,由于研究数量有限,表明HDV血清学测试,特别是那些鉴定抗IgG表现出很高的准确性,可以作为HDV的有效筛查工具。
Hepatitis Delta Virus (
HDV), a satellite virus of Hepatitis B virus, exacerbates liver damage in affected individuals. Screening for
HDV antibodies in HBsAg positive patients is recommended, but the diagnostic accuracy of serological tests remains uncertain. This review aimed to assess the diagnostic accuracy of serological tests for
HDV. We searched PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Scopus etc. for relevant studies. Studies measuring the sensitivity and specificity of serological HDV tests against PCR as a reference standard were included. Pooled sensitivity and specificity for each test method and sero-marker were calculated. The review included six studies with 11 study arms, evaluating ARCHITECT immunoassay, EIA, ELISA, QMAC, RIA, and Western Blot test methods targeting Anti-HDV IgG, Total anti-
HDV and Anti-
HDV IgM. Sensitivities for Anti-
HDV IgG, Total Anti-
HDV and Anti-
HDV IgM, tests were 97.4%, 51.9%, and 62.0%, respectively, with specificities of 95.3%, 80.0%, and 85.0%. Our findings, with its limited number of studies, suggest that HDV serological tests, particularly those identifying Anti IgG exhibit high accuracy and can serve as effective screening tools for HDV.