PDF(Pubmed)
Abstract：
The hepatitis D virus (HDV) is a compact, enveloped, circular RNA virus that relies on hepatitis B virus (HBV) envelope proteins to initiate a primary infection in hepatocytes, assemble, and secrete new virions. Globally, HDV infection affects an estimated 12 million to 72 million people, carrying a significantly elevated risk of developing cirrhosis, liver failure, and hepatocellular carcinoma (HCC) compared to an HBV mono-infection. Furthermore, HDV-associated HCC often manifests at a younger age and exhibits more aggressive characteristics. The intricate mechanisms driving the synergistic carcinogenicity of the HDV and HBV are not fully elucidated but are believed to involve chronic inflammation, immune dysregulation, and the direct oncogenic effects of the HDV. Indeed, recent data highlight that the molecular profile of HCC associated with HDV is unique and distinct from that of HBV-induced HCC. However, the question of whether the HDV is an oncogenic virus remains unanswered. In this review, we comprehensively examined several crucial aspects of the HDV, encompassing its epidemiology, molecular biology, immunology, and the associated risks of liver disease progression and HCC development.
摘要：
丁型肝炎病毒（HDV）是一种紧凑的病毒，信封,环状RNA病毒，依赖于乙型肝炎病毒（HBV）包膜蛋白启动肝细胞的原发性感染，组装,并分泌新的病毒体.全球范围内,HDV感染影响估计1200万至7200万人，患有肝硬化的风险显着升高，肝功能衰竭,与HBV单一感染相比，肝细胞癌（HCC）。此外，与HDV相关的HCC通常在更年轻的年龄表现出更积极的特征。驱动HDV和HBV的协同致癌性的复杂机制尚未完全阐明，但被认为涉及慢性炎症，免疫失调，和HDV的直接致癌作用。的确,最近的数据表明，与HDV相关的HCC的分子谱是独特的，与HBV诱导的HCC不同。然而,HDV是否是致癌病毒的问题仍未得到解答.在这次审查中,我们全面研究了HDV的几个关键方面，包括它的流行病学，分子生物学,免疫学,以及肝脏疾病进展和肝癌发展的相关风险。
