背景:久坐行为已被确定为代谢综合征(MetS)的重要危险因素。然而,目前尚不清楚久坐模式测量方法是否(姿势与运动)影响观察到的协会,或者如果西班牙裔/拉丁裔社区的协会不同,谁有更高的MetS风险。
方法:来自矿山社区(CoM)研究(N=602)的参与者佩戴髋部加速度计14天,并完成了MetS相关生物标志物评估(甘油三酯,血压,空腹血糖,HDL胆固醇,腰围)。使用切割点(基于运动)和卷积神经网络髋关节加速度计姿势(CHAP)算法(基于姿势)对久坐模式进行分类。我们使用逻辑回归来估计MetS与久坐模式之间的关联,并按西班牙裔/拉丁裔种族进行分层。
结果:CHAP和断点久坐模式与MetS一致相关。当控制总久坐时间和中等至剧烈的体力活动时,只有CHAP测量的中位久坐时间(OR=1.15,CI:1.04,1.28)是显著的.在分层分析中,CHAP测量的中位发作持续时间和久坐不动发作≥30分钟的时间均与MetS的几率增加相关,但西班牙裔/拉丁裔种族(OR=1.71和1.48;CI=1.28-2.31和1.12-1.98)的相关性比非西班牙裔/拉丁裔种族(OR=1.43和1.40;CI=1.10-1.87和1.06-1.87)更强.
结论:测量久坐模式的方式会影响与MetS关联的强度和精度。在西班牙裔/拉丁裔种族中,这些差异可能更大,因此需要进一步研究以告知这些人群的久坐行为干预措施。
BACKGROUND: Sedentary behavior has been identified as a significant risk factor for Metabolic Syndrome (MetS). However, it is unclear if the sedentary pattern measurement approach (posture vs. movement) impacts observed associations or if associations differ for Hispanic/Latino communities, who have higher risk of MetS.
METHODS: Participants from the Community of Mine (CoM) study (N = 602) wore hip-based accelerometers for 14 days and completed MetS-associated biomarker assessment (triglycerides, blood pressure, fasting glucose, HDL cholesterol, waist circumference). Sedentary patterns were classified using both cutpoints (movement-based) and the Convolutional Neural Network Hip Accelerometer Posture (CHAP) algorithm (posture-based). We used logistic regression to estimate associations between MetS with sedentary patterns overall and stratified by Hispanic/Latino ethnicity.
RESULTS: CHAP and cutpoint sedentary patterns were consistently associated with MetS. When controlling for total sedentary time and moderate to vigorous physical activity, only CHAP-measured median sedentary bout duration (OR = 1.15, CI: 1.04, 1.28) was significant. In stratified analysis, CHAP-measured median bout duration and time spent in sedentary bouts ≥ 30 min were each associated with increased odds of MetS, but the respective associations were stronger for Hispanic/Latino ethnicity (OR = 1.71 and 1.48; CI = 1.28-2.31 and 1.12-1.98) than for non-Hispanic/Latino ethnicity (OR = 1.43 and 1.40; CI = 1.10-1.87 and 1.06-1.87).
CONCLUSIONS: The way sedentary patterns are measured can impact the strength and precision of associations with MetS. These differences may be larger in Hispanic/Latino ethnic groups and warrants further research to inform sedentary behavioral interventions in these populations.