目标:低静息代谢率(RMR),作为体重增加和肥胖的危险因素,会受到许多因素的影响。实证研究证实了食欲和相关激素在肥胖和能量摄入中的作用。这项研究旨在调查正常和低RMR的超重或肥胖伊朗女性的食欲与相关激素之间的关系。
方法:本病例对照研究对42名伊朗成年女性(21例,和21个控件),18-48岁。使用阻抗体分析仪获得身体组成,并使用间接量热计评估RMR。弗林特问卷用于评估食欲,饮食摄入量,和体力活动分别通过FFQ和IPAQ问卷进行评估,和ELISA试剂盒用于评估瘦素,ghrelin,和胰岛素激素。
结果:研究结果表明,生长素释放肽激素水平(β=-0.34,95CI=-61.70,-3.86,P值=0.027)与RMR之间呈负相关,胰岛素激素水平(β=0.48,95CI=9.38-34.35,P值=0.001)与RMR呈正相关。此外,食欲问卷的结果显示,总的来说,食欲(β=0.32,95CI=-0.10-2.99P值=0.044)和饥饿变量(β=0.30,95CI=0.04-5.87,P值=0.047)均与RMR呈正相关。瘦素水平与RMR之间没有显着关联。
结论:显然,食欲和相关激素在促进正常RMR方面具有潜在作用。
OBJECTIVE: Low resting metabolic rate (RMR), as a risk factor for weight gain and obesity, can be influenced by many factors. Empirical research has confirmed the role of appetite and related hormones in obesity and energy intake. This study aimed to investigate the relationship between appetite and related hormones in overweight or obese Iranian women with normal and hypo RMR.
METHODS: This
case-control study was conducted on 42 Iranian adult women (21 cases, and 21 controls), aged 18-48 years. An impedance body analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. The Flint questionnaire was used to assess appetite, dietary intake, and physical activity were assessed by FFQ and IPAQ questionnaires respectively, and ELISA kits were used to assess leptin, ghrelin, and insulin hormones.
RESULTS: The results of the study demonstrated a negative association between ghrelin hormone level (β = -0.34, 95%CI = -61.70,-3.86, P-value = 0.027) and RMR, and a positive association between insulin hormone level (β = 0.48, 95%CI = 9.38-34.35, P-value = 0.001) and RMR. Also, results of the appetite questionnaire showed that, in general, both appetite (β = 0.32, 95%CI = -0.10-2.99 P-value = 0.044) and hunger variable (β = 0.30, 95%CI = 0.04-5.87, P-value = 0.047) have a positive association with RMR. There was no significant association between leptin levels and RMR.
CONCLUSIONS: It is evident that appetite and related hormones have a potential role in promoting a normal RMR.