目的:本研究旨在报告在密西西比州儿童医院接受治疗的颅骨融合(CS)患者的地理和人口统计学模式,该州唯一的美国唇裂颅面协会批准的颅面团队。
方法:从2015年到2020年,CS患者在三级儿科医院接受治疗,由颅面外科医生和神经外科医生照顾。人口统计,地理,和CS诊断细节,包括性,胎龄,种族,种族,保险状况,和受影响的颅骨缝合类型,number,和相关的综合征诊断被收集,包括出生县和来自州数据的活产总数。使用双尾t检验检查密西西比州四个地区CS患病率之间的显着差异(P<0.05)。
结果:在2015年至2020年期间,密西西比州的222,819名活产儿中,有79名儿科患者出现了CS,总发病率为0.355/1000活产。大多数病例是非综合征性CS(82%,n=65)影响单个主要颅骨缝合(81%,n=64)。与密西西比州东北部相比,沿海和中部地区的CS总体发病率较高,在0.333和0.527与0.132/1000活产(P=0.012和P=0.004),分别。
结论:这项研究的结果表明密西西比州CS的区域模式,这可能反映了密西西比州儿童的实际发病模式或接近情况。进一步的研究可以揭示该州不同地区CS发病率或获得专门CS护理的风险因素的区域差异。这将为机构外展提供机会,以减轻密西西比州的CS护理负担。
OBJECTIVE: This study aimed to report geographic and demographic patterns of patients with craniosynostosis (CS) treated at Children\'s of Mississippi, the state\'s only American Cleft Palate-Craniofacial Association-approved craniofacial team.
METHODS: Patients with CS were treated at a tertiary pediatric hospital cared for by craniofacial surgeons and neurosurgeons from 2015 to 2020. Demographic, geographic, and CS diagnosis details, including sex, gestational age, race, ethnicity, insurance status, and affected cranial suture type(s), number, and associated syndromic diagnosis were collected, including birth county and total live births from state data. Significant differences between prevalence of CS in four regions of Mississippi were examined using two-tailed t tests (P < 0.05).
RESULTS: Among 222,819 live births in Mississippi between 2015 and 2020, 79 pediatric patients presented to Children\'s of Mississippi with CS, with an overall incidence of 0.355/1000 live births. Most cases were nonsyndromic CS (82%, n = 65) affecting a single major cranial suture (81%, n = 64). The overall incidence of CS was higher in the coastal and central regions compared with northeast Mississippi, at 0.333 and 0.527 vs 0.132/1000 live births (P = 0.012 and P = 0.004), respectively.
CONCLUSIONS: Results from this study suggest regional patterns of CS in Mississippi, which may reflect actual incidence patterns or proximity to Children\'s of Mississippi. Further study could reveal regional differences in risk factors underlying CS incidence or access to specialized CS care for different regions in the state. This will lead to opportunities for institutional outreach to decrease the burden of CS care in Mississippi.