■主动脉,心血管系统的核心组成部分,在确保血液循环方面起着举足轻重的作用。尽管它很重要,明显缺乏用于实验和计算研究的理想化模型。
■这项研究旨在为理想化的人类主动脉开发计算机辅助设计(CAD)模型,用于在体外和计算机环境中研究血液动力学或固体力学。
■从综合文献中提取各种参数,以评估健康成人主动脉的主要解剖特征,包括主动脉弓分支和相应尺寸的变化。理想化模型是根据每个研究的队列大小加权的平均值生成的,该平均值是从基于图像或尸体的研究中收集和汇编的几个形态学参数。以及来自四名招募受试者的数据。使用粒子图像测速(PIV)测量和计算流体动力学(CFD)模拟,将模型用于血液动力学评估。
■开发了两种理想化的人主动脉CAD模型,关注健康人口。CFD模拟,与PIV测量结果密切相关,捕获在患者特定病例中观察到的主要整体流动特征和壁剪应力模式,展示设计模型的功能。
■收集的关于主动脉和两个理想化主动脉模型的统计数据,涵盖了常见的足弓变体,称为正常和牛类型,被证明可用于检查主动脉的血液动力学。它们还为需要解剖统计的医疗设备的设计应用提供了希望。
UNASSIGNED: The aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation. Despite its importance, there is a notable lack of idealized models for experimental and computational studies.
UNASSIGNED: This study aims to develop computer-aided design (CAD) models for the idealized human aorta, intended for studying hemodynamics or solid mechanics in both in vitro and in silico settings.
UNASSIGNED: Various parameters were extracted from comprehensive literature sources to evaluate major anatomical characteristics of the aorta in healthy adults, including variations in aortic arch branches and corresponding dimensions. The idealized models were generated based on averages weighted by the cohort size of each study for several morphological parameters collected and compiled from image-based or cadaveric studies, as well as data from four recruited subjects. The models were used for hemodynamics assessment using particle image velocimetry (PIV) measurements and computational fluid dynamics (
CFD) simulations.
UNASSIGNED: Two CAD models for the idealized human aorta were developed, focusing on the healthy population. The
CFD simulations, which align closely with the PIV measurements, capture the main global flow features and wall shear stress patterns observed in patient-specific cases, demonstrating the capabilities of the designed models.
UNASSIGNED: The collected statistical data on the aorta and the two idealized aorta models, covering prevalent arch variants known as Normal and Bovine types, are shown to be useful for examining the hemodynamics of the aorta. They also hold promise for applications in designing medical devices where anatomical statistics are needed.