%0 Journal Article %T Experimental and CFD analysis of fluid flow through nanofiber filter media. %A Azimian M %A Naderi M %A Soltani P %A Cheng L %A Naderi K %A Linden S %A Wiegmann A %J Sci Rep %V 14 %N 1 %D 2024 Jul 12 %M 38997418 %F 4.996 %R 10.1038/s41598-024-67066-x %X This work presents a novel approach to investigating the slip effect in nanofiber filter media. Electrospun nanofiber media with high efficiency and low pressure drop were produced at different concentrations and durations. The surface and cross-sectional morphology of nanofiber media were studied using FE-SEM. Fiber orientation and diameter distributions were also examined. The 3D virtual nanofiber media was modeled using this information along with the experimentally measured porosity and thickness of the media. The effect of the slip phenomenon in nanofiber media was studied numerically, and the results were compared to experimental data. Excellent agreements were found between the measured and simulation results. Additionally, filtration simulations considering aerosols injected with airflow through the nanofibrous filter media were conducted by considering the slip effect, and the effect of filter structure on filtration performance (removal efficiency and pressure drop) was investigated.