背景/目的:目前尚不清楚非侵入性生物标志物对儿童过敏性疾病的诊断和监测的重要性。从这个角度来看,关于成年前总(t)免疫球蛋白E(IgE)在不同年龄组不同过敏性疾病中的作用的数据尚不清楚.tIgE水平与在专门的三级过敏中心诊断的过敏性疾病类型的潜在关联,关于性别和从出生到20岁的年龄组,在本研究中进行了评估。方法:在这项回顾性研究中,tIgE值来自于2015年1月至2020年12月在我们科室评估过敏相关症状的儿童.分析tIgE值与年龄和诊断的关系。结果:数据来自2127例患者(1321名男孩(62.1%)),年龄中位数为6.31(3.01-9.95)岁,可用。研究人群的tIgE中值为132(37.7-367.5)kU/lt。tIgE值显示从0-2年到2-5年和5-12年的显着增加,但不是从5-12到12-20年。与女孩相比,男孩表现出明显更高的tIgE值。此外,哮喘患儿的tIgE水平显著升高,过敏性鼻炎,食物过敏,与没有这些诊断的儿童相比,特应性皮炎。结论:过敏性疾病患儿总IgE值呈现显著且进行性的纵向增加,特别是在0-2和5-12年龄组,在男孩中,以及被诊断患有特应性疾病的儿童。
Background/Objectives: The importance of non-invasive biomarkers for the diagnosis and monitoring of allergic diseases in childhood is currently unknown. From this perspective, data on the role of the total (t) immunoglobulin E (IgE) in relation to different allergic diseases across different age groups until adulthood remain unclear. The potential association of tIgE levels with types of allergic diseases diagnosed in an specialized tertiary
allergy center, in relation to sex and the age group spanning from birth to 20 years, are evaluated in the present study. Methods: In this retrospective study, the tIgE values were obtained from children assessed for
allergy-associated symptoms in our department from January 2015 to December 2020. The tIgE values were analyzed in relation to age and diagnosis. Results: Data from 2127 patients (1321 boys (62.1%)), with a median age of 6.31 (3.01-9.95) years, were available. The tIgE median values for the studied population were 132 (37.7-367.5) kU/lt. The tIgE values showed a significant increase from 0-2 years to 2-5 and 5-12 years, but not from 5-12 to 12-20 years. Boys exhibited significantly higher tIgE values compared to girls. Furthermore, the tIgE levels were significantly increased in children with asthma, allergic rhinitis, food
allergy, and atopic dermatitis in comparison to children without these diagnoses. Conclusions: The total IgE values exhibit a significant and progressive longitudinal increase in children with allergic diseases, particularly notable in the 0-2 and 5-12 age groups, in boys, and in children diagnosed with atopic conditions.