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Abstract：
The aim was to evaluate the prediction of house dust mite allergy in children diagnosed with allergic disease based on their skin moisture and sebum levels. This is a case-control study including children with asthma, allergic rhinitis (AR), and atopic dermatitis (AD) and a healthy control group. The participants\' skin moisture and sebum levels were measured non-invasively using a digital device. A total of 421 patients and 143 healthy children were included. The median value of skin moisture percentage was statistically significantly lower in asthma, AR, and AD patients compared to the control group (p < 0.001 for each). The median value of skin sebum percentage was significantly lower in asthma and AD patients compared to the control group (p = 0.002 and p = 0.003, respectively). ROC analysis was performed to assess the predictive value of skin moisture percentage for house dust mite allergy in respiratory allergic diseases (asthma and AR) and AD separately. Using a cut-off point of 35.5% for skin moisture in asthma and AR patients, the sensitivity and specificity were 81.3% and 56.5%, respectively. Although the specificity is low, the high sensitivity value is promising. The non-invasive measurement of skin sebum and moisture could provide convenience to clinicians in the diagnosis and management of allergic diseases.
摘要：
目的是根据皮肤水分和皮脂水平评估被诊断患有过敏性疾病的儿童对屋尘螨过敏的预测。这是一项病例对照研究，包括哮喘儿童，过敏性鼻炎（AR），特应性皮炎（AD）和健康对照组。使用数字设备非侵入性地测量参与者的皮肤水分和皮脂水平。共纳入421例患者和143例健康儿童。哮喘患者皮肤水分百分比的中位值显著降低，AR,和AD患者与对照组相比（每组p<0.001）。与对照组相比，哮喘和AD患者的皮肤皮脂百分比的中位值显着降低（分别为p=0.002和p=0.003）。分别进行ROC分析以评估皮肤水分百分比对呼吸道过敏性疾病（哮喘和AR）和AD中屋尘螨过敏的预测价值。使用35.5%的临界点对哮喘和AR患者的皮肤水分，敏感性和特异性分别为81.3%和56.5%，分别。虽然特异性很低，高灵敏度值是有希望的。皮肤皮脂和水分的无创测量可以为临床医生诊断和治疗过敏性疾病提供便利。
