■头颈部鳞状细胞癌（HNSC）是第六大最常见的肿瘤，总生存率为40-50%。HNSC标准治疗取决于肿瘤大小，转移或人乳头瘤病毒（HPV）状态，包括手术，化疗,和放射治疗。后两种可能导致肿瘤微环境和癌细胞生物学缺陷，如DNA损伤修复系统的紊乱。这里,我们评估了XPC基因中的单核苷酸多态性（SNP）rs2228001与放疗早期和晚期不良反应之间的相关性，确定HNSC患者的SNP分布和治疗后随访。
■获得79例患者的头颈部癌组织和临床资料。用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）评估XPC基因（rs2228001）的SNP。采用卡方检验确定突变与不良反应发生的相关性。
■XPC基因中的单核苷酸多态性rs2228001与HNSC患者皮肤反应的早期不良反应和C反应蛋白（CRP）水平升高的晚期不良反应相关。
UNASSIGNED: Head and neck squamous carcinoma (HNSC) is the sixth most common neoplasm, with a 40-50% overall survival rate. HNSC standard treatment depends on tumor size, metastasis or human papillomavirus (HPV) status including surgery, chemotherapy, and radiotherapy. The last two may lead to defects in the tumor microenvironment and cancer cell biology as disorders in DNA damage repair systems. Here, we evaluate the correlation between single nucleotide polymorphism (SNP) rs2228001 in the XPC gene with the early and late adverse effects of radiotherapy, determine the distribution of the SNP and post-treatment follow-up in HNSC patients.
UNASSIGNED: Head and neck cancer tissues and clinical data were obtained from 79 patients. The SNP of the XPC gene (rs2228001) was evaluated with polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP). The chi-square test was used to determine the correlation between mutation and adverse effects occurrence.
UNASSIGNED: Single nucleotide polymorphism rs2228001 in the XPC gene is correlated with the early adverse effect of skin reaction and the late adverse effect of elevated C-reactive protein (CRP) levels in the HNSC patients.
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