■我们的目标是通过对所有现有证据进行总括性审查来探索高压氧在治疗突发性感觉神经性听力损失中的功效。
■我们进行了综述,在PubMed中搜索相关文章,WebofScience,Embase,和Scopus数据库。搜索期从每个数据库开始到2024年4月。我们提取了作者,出版国,出版时间,纳入研究和参与者的数量,干预措施,结果总结,P值,I2,相对风险(95%CI),和结果措施。方法的质量,证据质量,并使用AMSTAR2级评估纳入文章的重叠率,和OVErviews(GROOVE)。
■使用AMSTAR2评估方法学质量。在九篇文章中,两人被评估为“高”,“三如”适度,\“两个为\”低,“剩下的两个”很低。“使用分级系统评估证据质量。结果发现,大多数研究的证据质量并不令人满意。发现所包含的文章之间有轻微的重叠。六项研究报告了阳性结果(OR1.37;95%CI,1.17-1.61;P=0.04),观察到高度异质性(I2=63%)。Egger检验表明存在偏差(P=0.000101)。三项研究报告阴性结果(MD1.49;95%CI,-0.32至3.29;P=0.43;I2=0%),根据Egger检验,没有检测到显著偏差(P=0.106)。
■HBO疗法被证明是SSNHL的有效治疗方法,副作用较少。然而,纳入本研究的系统综述和荟萃分析的方法学质量和证据普遍较低.因此,更高质量,大规模,未来需要多中心随机对照试验来验证HBO治疗SSNHL的疗效.
■https://www.crd.约克。AC.英国/普劳里,标识符[CRD42024523651]。
UNASSIGNED: Our objective was to explore the efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss by conducting an umbrella review of all existing evidence.
UNASSIGNED: We conducted an umbrella review, searching for related articles in the PubMed, Web of Science, Embase, and Scopus databases. The search period covered from the inception of each database until April 2024. We extracted authors, country of publication, time of publication, number of included studies and participants, interventions, summary of results, P-values, I 2, relative risk (95% CI), and outcome measures. The methodological quality, evidence quality, and overlap rate of the included articles were assessed using AMSTAR 2, GRADE, and OVErviews (GROOVE).
UNASSIGNED: Methodological quality was assessed using AMSTAR 2. Of the nine included articles, two were assessed as \"high,\" three as \"moderate,\" two as \"low,\" and the remaining two as \"very low.\" The quality of evidence was assessed using the GRADE system. It was found that the quality of evidence in most of the studies was unsatisfactory. It was found that there was a slight overlap among the included articles. Six studies reported positive results (OR 1.37; 95% CI, 1.17-1.61; P = 0.04), with high heterogeneity observed (I 2 = 63%). Egger\'s test indicated bias (P = 0.000101). Three studies reported negative results (MD 1.49; 95% CI, -0.32 to 3.29; P = 0.43; I 2 = 0%), with no significant bias detected (P = 0.106) according to Egger\'s test.
UNASSIGNED: HBO therapy is shown to be an effective treatment for SSNHL with fewer side effects. However, the methodological quality and evidence of the systematic reviews and meta-analysis included in this study were generally low. Therefore, more high-quality, large-scale, multi-center randomized controlled trials are needed in the future to verify the efficacy of HBO therapy for SSNHL.
UNASSIGNED: https://www.crd.york.ac.uk/prospero, identifier [CRD42024523651].