■帕金森病(PD)早期患者可能存在细微的认知缺陷,而明显的认知缺陷通常是晚期PD的表现。关于脑深部电刺激(DBS)对PD患者认知功效的后果仍存在争议。本研究旨在探讨丘脑底核(STN)-DBS与药物治疗和其他方法相比对PD患者术后痴呆的影响。
■我们搜索了PubMed,Scopus,科克伦图书馆,和2020年10月的WebofScience数据库,关键字:“深部脑刺激,\"\"帕金森病,\"\"痴呆症,\"和\"内存。\"评论,摘要,案例介绍,字母被排除在外。
■总共,在去除重复后筛选491项研究。筛选结果产生了81篇待筛选合格的文章。最后,该综合荟萃分析中包括6项研究。总的来说,800名患者被纳入本荟萃分析,使用马蒂斯痴呆评定量表(MDRS)和从文章中提取的描述性数据来评估全球痴呆。
■我们的结果表明,STN-DBS组比接受最佳药物治疗(BMT)的患者表现出更大的认知能力下降。然而,比较STN-DBS与苍白球内刺激和苍白球切开术,不能证明对患者的整体痴呆有显著的统计学影响.需要更多具有更大样本量的长期研究来验证当前的发现。
UNASSIGNED: Patients in the early stages of Parkinson disease (PD) may have subtle cognitive deficits, while overt cognitive deficits are usually manifestations of late-stage PD. There is still a debate on the outcome of deep brain stimulation (DBS) on the cognitive function of PD patients. This study aimed to investigate the effect of subthalamic nucleus (STN)-DBS on the dementia of PD patients after surgery compared to medical therapy and other procedures.
UNASSIGNED: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: \"Deep brain stimulation,\" \"Parkinson disease,\" \"dementia,\" and \"memory.\" Reviews, abstracts, case presentations, and letters were excluded.
UNASSIGNED: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia.
UNASSIGNED: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings.