screw

螺钉
  • 文章类型: Journal Article
    背景:机械并发症会影响植入物修复体的稳定性,并且是临床医生关注的重点,特别是随着频繁引入具有各种结构和材料的新植入物设计。本研究使用计算机模拟和体外方法评估了不同假体指数结构类型和植入物材料对植入物修复体应力分布的影响。
    方法:创建了四个种植体修复体的有限元分析(FEA)模型,结合两种假体指数结构(交叉配合(CF)和Torc配合(TF))和两种植入材料(钛和钛锆)。对每组施加静载荷。使用数字图像相关(DIC)的体外研究与FEA相同的研究方案进行验证。主要菌株,敏感性指数,并使用等效的冯·米塞斯压力来评估结果。
    结果:将植入物材料从钛改为钛锆并没有显着影响其他组件的应力分布或最大应力值,除了植入物本身。在CF组中,具有较低弹性模量的植入物增加了螺钉上的应力。TF组的基台应力分布较好,螺钉应力值较低。TF组对所有组分表现出相似的灵敏度。DIC分析显示,TF-TiZr和CF-Ti在植入物上的最大主应变(P<0.001)和最小主应变(P<0.05)以及两组投资材料上的最小主应变方面存在显着差异(P<0.001)。
    结论:植入材料的变化显著影响了植入物的最大应力。TF组表现出更好的结构完整性和可靠性。
    BACKGROUND: Mechanical complications affect the stability of implant restorations and are a key concern for clinicians, especially with the frequent introduction of new implant designs featuring various structures and materials. This study evaluated the effect of different prosthetic index structure types and implant materials on the stress distribution of implant restorations using both in silico and in vitro methods.
    METHODS: Four finite element analysis (FEA) models of implant restorations were created, incorporating two prosthetic index structures (cross-fit (CF) and torc-fit (TF)) and two implant materials (titanium and titanium-zirconium). A static load was applied to each group. An in vitro study using digital image correlation (DIC) with a research scenario identical to that of the FEA was conducted for validation. The primary strain, sensitivity index, and equivalent von Mises stress were used to evaluate the outcomes.
    RESULTS: Changing the implant material from titanium to titanium-zirconium did not significantly affect the stress distribution or maximum stress value of other components, except for the implant itself. In the CF group, implants with a lower elastic modulus increased the stress on the screw. The TF group showed better stress distribution on the abutment and a lower stress value on the screw. The TF group demonstrated similar sensitivity for all components. DIC analysis revealed significant differences between TF-TiZr and CF-Ti in terms of the maximum (P < 0.001) and minimum principal strains (P < 0.05) on the implants and the minimum principal strains on the investment materials in both groups (P < 0.001).
    CONCLUSIONS: Changes in the implant material significantly affected the maximum stress of the implant. The TF group exhibited better structural integrity and reliability.
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  • 文章类型: Journal Article
    本研究旨在使用有限元分析来分析通过新型解剖钢板固定的后外侧平台骨折的生物力学特征。
    通过CT扫描获得了右胫腓骨全长的三维数字模型。然后创建胫骨平台后外侧骨折模型。获得的骨折模型与4组内固定:A组,新型解剖钢板;B组,直支撑板;C组,斜T形锁定板;D组,两个方头螺钉。垂直于水平面的500、1,000和1,500N的轴向载荷用于模拟65公斤站立的人的侧向高原上的应力,步行和快速跑步。
    四组中每一组的后外侧碎片的垂直位移在从500N到1,500N的载荷下逐渐增加。四组中的骨折碎片的最大位移都位于近端部分的侧面,位移从近端到远端逐渐减小。1,500N轴向载荷下的最大位移值依次为:新型解剖板(1.2365mm)<斜T形锁定板(1.314mm)<两个拉力螺钉(1.3747mm)<直支撑板(1.3932mm)。随着轴向载荷的增加,不同内固定模型的应力值逐渐增加。同一内固定模型在不同载荷下的应力行为相似。1,500N轴向载荷下的最大应力值依次为:新型解剖板(114.63MPa)<斜T形锁定板(277.17MPa)<两个拉力螺钉(236.75MPa)<直支撑板(136.2MPa)。
    平台后外侧骨折患者用新型解剖钢板站立固定,步行和快速跑步可以达到令人满意的生物力学效果,为未来的应用奠定了基础。同时,临床骨折类型通常多种多样,并伴有软组织损伤。因此,必须根据患者的受伤情况选择理想的手术方式和适当的内固定。
    UNASSIGNED: This study aims to analyze the biomechanical characteristics of posterolateral plateau fractures fixed by a novel anatomical plate using finite element analysis.
    UNASSIGNED: A three-dimensional digital model of the full length of right tibiofibula was obtained by CT scanning. A posterolateral tibial plateau fracture model was then created. The acquired fracture model was assembled with 4 groups of internal fixations: Group A, novel anatomical plate; Group B, straight buttress plate; Group C, oblique T-shaped locking plate; Group D, two lag screws. Axial loads of 500, 1,000 and 1,500 N perpendicular to the horizontal plane were used to simulate the stress on the lateral plateau of a 65 kg person standing, walking and fast running.
    UNASSIGNED: Vertical displacements of the posterolateral fragments in each of the four groups gradually increased under loads from 500 N to 1,500 N. The maximum displacement of the fracture fragment in four groups were all located on the lateral side of the proximal part, and the displacement gradually decreased from the proximal part to the distal end. The maximum displacement values under the axial load of 1,500 N was in the following order: novel anatomical plate (1.2365 mm) < oblique T-shaped locking plate (1.314 mm) < two lag screws (1.3747 mm) < straight buttress plate (1.3932 mm). As the axial load increased, the stress value of the different internal fixation models gradually increased. The stress behavior of the same internal fixation model under different loads was similar. The maximum stress value under the axial load of 1,500 N was in the following order: novel anatomical plate (114.63 MPa) < oblique T-shaped locking plate (277.17 MPa) < two lag screws (236.75 MPa) < straight buttress plate (136.2 MPa).
    UNASSIGNED: The patients with posterolateral plateau fractures fixed with a novel anatomical plate in standing, walking and fast running can achieve satisfactory biomechanical results, which lays the foundation for future applications. At the same time, clinical fracture types are often diverse and accompanied by damage to the soft tissue. Therefore, the ideal surgical approach and appropriate internal fixation must be selected based on the patient\'s injury condition.
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  • 文章类型: Case Reports
    双侧大结节合并肩关节前内脱位的骨折极为罕见,由于其罕见的发生和缺乏标准化的管理方案,在治疗中提出了挑战。
    方法:我们报告了一例22岁的患者,该患者在癫痫发作后出现双侧前肩关节脱位并伴有大结节骨折。临床讨论:我们病例的独特之处在于异常的损伤机制。与典型的惊厥性癫痫发作不同,这通常会导致双侧后脱位,我们的患者患有双侧前脱位和大结节骨折。大结节骨折的治疗管理缺乏标准化的方法,但如果位移超过0.5厘米,手术干预是必要的。治疗方案包括切开复位内固定(ORIF),经皮螺钉固定,用缝合锚进行双排修复的关节镜手术,或关节镜技术和螺钉固定的组合。对于碎片较大的粉碎性骨折,建议使用ORIF与钢板接骨术。为了评估功能结果,常用的评分系统包括加州大学洛杉矶分校肩部评分,ASES评分,和Constant-MurleyScore.
    结论:双侧肩关节前脱位合并大结节骨折的发生率极为罕见。鉴于其解剖病理学意义和对功能恢复的影响,仔细和个性化的治疗大结节骨折是至关重要的,考虑到它作为肩袖肌腱插入点的作用。
    UNASSIGNED: Bilateral combined fractures of the greater tuberosity with anterior internal shoulder dislocation are extremely rare, presenting challenges in treatment due to their uncommon occurrence and lack of standardized management protocols.
    METHODS: We report the case of a 22-year-old patient who experienced bilateral anterior shoulder dislocations with associated fractures of the greater tuberosities following a seizure-induced fall. Clinical Discussion: The unique aspect of our case is the unusual mechanism of injury. Unlike typical convulsive seizures, which often result in bilateral posterior dislocations, our patient suffered bilateral anterior dislocations and fractures of the greater tuberosities. Therapeutic management of greater tuberosity fractures lacks a standardized approach, but surgical intervention is warranted if displacement exceeds 0.5 cm. Treatment options include open reduction and internal fixation (ORIF), percutaneous screw fixation, arthroscopic procedures with suture anchors for double-row repair, or a combination of arthroscopic techniques and screw fixation. ORIF with plate osteosynthesis may be recommended for comminuted fractures with large fragments. To assess functional outcomes, commonly used scoring systems include the UCLA Shoulder Score, ASES Score, and Constant-Murley Score.
    CONCLUSIONS: Bilateral anterior shoulder dislocation associated with combined fractures of the greater tuberosity is an extremely rare occurrence. Given its anatomopathological significance and impact on functional recovery, careful and individualized management of greater tuberosity fractures is crucial, considering its role as a point of insertion for the rotator cuff tendons.
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  • 文章类型: Case Reports
    背景:跟骨结节的撕脱性骨折伴明显移位可引起足跟软组织并发症。然而,跟骨结节骨折的治疗策略尚待确定。这里,我们报告了一例跟骨结节撕脱性骨折,表现为浅表皮肤坏死,采用缺少前组件的钢板和经皮螺钉治疗。
    方法:一名74岁女性在足跟损伤后出现进行性右足跟疼痛,大约在六周前。由于脚跟疼痛,她经历了行走困难,并且在脚跟的后表面观察到浅表坏死。X线摄影和计算机断层扫描显示跟骨结节撕脱性骨折,并有较高的移位。使用侧向L形切口进行切开复位。将两个松质骨螺钉经皮插入跟骨结节后,我们在跟骨侧面固定了一块缺少前部成分的钢板。浅表坏死术后逐渐愈合。术后6个月使用X线照相术确认骨愈合。
    结论:我们开发了一种新的手术方法来治疗皮肤状况较差的跟骨结节撕脱性骨折。缺少前部组件的钢板和经皮插入导管松质螺钉的组合可以降低术后软组织并发症的风险,同时保持骨折碎片的固定。
    结论:我们的发现为治疗跟骨结节撕脱性骨折伴软组织并发症提供了一种新的手术方法。
    BACKGROUND: Avulsion fractures of the calcaneal tuberosity with significant displacement can cause soft tissue complications in the heel. However, a treatment strategy for calcaneal tuberosity fractures with poor heel-skin condition is yet to be established. Here, we report a case involving avulsion fracture of the calcaneal tuberosity presenting with superficial skin necrosis that was treated with a plate lacking the anterior component and screws inserted percutaneously.
    METHODS: A 74-year-old woman presented with progressive right heel pain following an injury to her heel sustained approximately six weeks previously. She had experienced difficulty walking due to heel pain and superficial necrosis was observed on the posterior surface of the heel. Radiography and computed tomography revealed an avulsion fracture of the calcaneal tuberosity with superior displacement. Open reduction was performed using a lateral L-shaped incision. After inserting two cancellous screws percutaneously into the calcaneal tuberosity, we fixed a plate lacking the anterior component to the lateral surface of the calcaneus. The superficial necrosis healed gradually post-operatively. Bone union was confirmed using radiography six months post-operatively.
    CONCLUSIONS: We developed a novel surgical procedure to treat avulsion fractures of the calcaneal tuberosity with poor skin condition. The combination of a plate lacking the anterior component and the percutaneous insertion of canulated cancellous screws can reduce the risk of post-operative soft tissue complications while maintaining fixation of the fractured fragment.
    CONCLUSIONS: Our findings provide a novel surgical method for the treatment of avulsion fractures of the calcaneal tuberosity with soft tissue complications.
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  • 文章类型: Journal Article
    骨折的控制动力学可以通过骨痂的形成促进骨折的自然愈合,而过于僵硬的固定会抑制愈合。锁定电镀技术的出现为裂缝的受控动力学提供了新的策略,例如远皮质锁定(FCL)螺钉或具有弹性悬挂螺钉孔的活动板。然而,这些策略不允许使用非锁定螺钉,通常用于减少骨板碎片。这项研究记录了关于用高级活动板(AAP)稳定的绵羊胫骨截骨术愈合的第一个体内研究。该AAP允许使用锁定和非锁定螺钉的任何组合来支持广泛的板应用技术的板应用。手术后第9周,收获胫骨,并在扭转失败的情况下进行测试,以评估愈合强度。用AAP稳定的五个胫骨恢复了其天然强度的54%,并因通过螺钉孔的螺旋断裂而失败,这不涉及愈合的截骨术。相比之下,用标准锁定钢板稳定的胫骨恢复了17%的强度,并通过截骨术持续失败。这些结果进一步支持受控运动对骨折愈合的刺激作用。因此,锁定钢板构造的受控动力学可能具有减少愈合并发症的潜力,并可能缩短恢复功能的时间。将受控动力学集成到支持标准固定技术的骨折钢板中可以促进动态钢板的临床采用。
    The controlled dynamization of fractures can promote natural fracture healing by callus formation, while overly rigid fixation can suppress healing. The advent of locked plating technology enabled new strategies for the controlled dynamization of fractures, such as far cortical locking (FCL) screws or active plates with elastically suspended screw holes. However, these strategies did not allow for the use of non-locking screws, which are typically used to reduce bone fragments to the plate. This study documents the first in vivo study on the healing of ovine tibia osteotomies stabilized with an advanced active plate (AAP). This AAP allowed plate application using any combination of locking and non-locking screws to support a wide range of plate application techniques. At week 9 post-surgery, tibiae were harvested and tested in torsion to failure to assess the healing strength. The five tibiae stabilized with an AAP regained 54% of their native strength and failed by spiral fracture through a screw hole, which did not involve the healed osteotomy. In comparison, tibiae stabilized with a standard locking plate recovered 17% of their strength and sustained failure through the osteotomy. These results further support the stimulatory effect of controlled motion on fracture healing. As such, the controlled dynamization of locked plating constructs may hold the potential to reduce healing complications and may shorten the time to return to function. Integrating controlled dynamization into fracture plates that support a standard fixation technique may facilitate the clinical adoption of dynamic plating.
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  • 文章类型: Journal Article
    简介:琼斯骨折经常无法团结,和足够的固定稳定性是至关重要的。这项研究旨在阐明各种髓内螺钉固定结构的生物力学稳定性。方法:在所有标本中建立人工骨第5跖骨近端Jones骨折模型。根据不同螺钉长度的螺钉结构分为六组,30或40毫米,包括空心螺钉-C30和C40组,一根高阻缝线结合髓内空心螺钉(F.E.R.I.technical)-CF30和CF40组,和第二代无头压紧螺钉(SG-HCS)-HL30和HL40组。机械测试是按顺序进行的,记录所有构建体的最大力(N)和刚度(N/mm)。结果:C30,C40,CF30,CF40,HL30和HL40组向下位移1.0mm时的最大力(N)分别为0.56±0.02,0.49±0.02,0.65±0.02,0.49±0.01,0.68±0.02和0.73±0.02。亚组的刚度(N/mm)分别为0.49±0.01、0.43±0.01、0.67±0.01、0.42±0.01、0.61±0.01和0.58±0.02。SG-HCS亚组表现出比常规空心螺钉更大的最大力和刚度。在每个亚组中,30mm长度的螺钉表现出比所有40mm长度的螺钉更好的稳定性。在C30固定中,刚度和最大力分别增加了1.16和1.12倍,分别,与C40固定方法相比。CF30和SG-HCS组之间无显著差异。只有F.E.R.I技术与长度为30mm的4.5mm空心螺钉相结合,才能提高Jones骨折的生物力学稳定性。讨论:这些生物力学发现有助于临床医生决定更好的螺钉固定方案,以提高琼斯骨折的稳定性。特别是大直径螺钉在使用中受到限制时。然而,这项针对Jones骨折模型的髓内螺钉固定的生物力学测试缺乏临床验证,也无法与髓外钢板固定进行比较.往前走,需要进行更多的临床和生物力学研究来验证我们的发现.
    Introduction: Jones fractures frequently fail to unite, and adequate fixation stability is crucial. This study aimed to elucidate the biomechanical stability of various intramedullary screw fixation constructs. Methods: Jones fracture model over the proximal 5th metatarsal of artificial bone was created in all specimens. Six groups were divided based on varied screw constructs with different screw lengths, either 30 or 40 mm, including cannulated screws-C30 and C40 groups, one high-resistance suture combined with intramedullary cannulated screws (F.E.R.I. technique)-CF30 and CF40 groups, and second-generation headless compression screws (SG-HCS) -HL30 and HL40 groups. Mechanical testing was conducted sequentially, and the maximal force (N) and stiffness (N/mm) of all constructs were recorded. Results: The maximal force (N) at 1.0 mm downward displacement in C30, C40, CF30, CF40, HL30, and HL40 groups were 0.56 ± 0.02, 0.49 ± 0.02, 0.65 ± 0.02, 0.49 ± 0.01, 0.68 ± 0.02, and 0.73 ± 0.02, respectively, and the stiffness (N/mm) in subgroups were 0.49 ± 0.01, 0.43 ± 0.01, 0.67 ± 0.01, 0.42 ± 0.01, 0.61 ± 0.01, and 0.58 ± 0.02, respectively. SG-HCS subgroups exhibited greater maximal force and stiffness than conventional cannulated screws. Screws of 30 mm in length demonstrated better stability than all 40 mm-length screws in each subgroup. In C30 fixation, the stiffness and maximum force endured increased by 1.16 and 1.12 times, respectively, compared with the C40 fixation method. There were no significant differences between CF30 and SG-HCS groups. Only the F.E.R.I technique combined with the 4.5 mm cannulated screw of 30 mm in length increased the biomechanical stability for Jones fractures. Discussion: These biomechanical findings help clinicians decide on better screw fixation options for greater stability in Jones fractures, especially when large-diameter screws are limited in use. However, this biomechanical testing of intramedullary screw fixation on Jones fracture model lacks clinical validation and no comparisons to extramedullary plate fixations. Moving forward, additional clinical and biomechanical research is necessary to validate our findings.
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  • 文章类型: Journal Article
    Akin截骨术通常用于矫正指间外翻(HVI)畸形。用于固定的首选植入物仍然是一个争论的领域,经常受到外科医生的倾向和专业知识的影响。这篇综述比较了当代在Akin截骨术中使用的固定方法的结果。PubMed是搜索的主要电子数据库。干预措施包括使用螺钉,订书钉(S),和缝合线。考虑的参与者是18岁及以上的成年人,进行Akin截骨术作为主要手术或辅助手术。排除通过经皮或微创方法进行的截骨术。分析了七项涉及590英尺的研究,展示了令人印象深刻的99.8%的整体工会率。总体并发症的发生率为8.98%,螺钉固定组的金属突出率明显更高(10.5%)。所有研究均显示术后放射学角度改善。螺丝,订书钉,和缝线固定表现出优异的愈合率。虽然螺钉和钉提供坚固的截骨固定,它们具有金属刺激和突出的风险。缝合固定以更低的成本提供与其他两种稳定方法相当的结果。
    Akin osteotomy is commonly used to correct hallux valgus interphalangeus (HVI) deformity. The preferred implant for fixation remains an area of debate, often influenced by the surgeon\'s inclinations and expertise. This review compares the outcomes of contemporary fixation methods utilized in Akin osteotomy. PubMed served as the primary electronic database for the search. The interventions encompassed the use of screw(s), staple(s), and suture(s). The participants considered were adults aged 18 and above, undergoing Akin osteotomy either as a primary procedure or as an adjunct. Excluded were osteotomies performed via percutaneous or minimally invasive methods. Seven studies involving 590 feet were analysed, showcasing an impressive 99.8% overall union rate. The incidence of overall complications stood at 8.98%, with metal prominence notably higher in the screw fixation group (10.5%). All studies exhibited postoperative improvement in radiological angles. Screw, staple, and suture fixations demonstrated excellent union rates. While screws and staples offer robust osteotomy fixation, they pose risks of metal irritation and prominence. Suture fixation delivers comparable outcomes to the other two stabilization methods at a lower cost.
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  • 文章类型: Journal Article
    后踝骨折(PMFs)(OTA43B1.1)常与腓骨骨折结合,内踝,和胫骨远端;它们很少能孤立地看到。PMFs影响踝关节的对齐和关节联合的稳定性。用于固定PMF的技术包括通过后外侧或后内侧入路或前后螺钉固定的切开复位内固定。对于选定的最小移位或非移位的后踝骨折,我们开发了一种通过跟腱的经皮技术,用于插入前后空心螺钉。描述了该技术,并对临床系列进行了回顾。
    Posterior malleolus fractures (PMFs) (OTA 43B1.1) are frequently seen in combination with fractures of the fibula, medial malleolus, and distal tibia; they can rarely be seen in isolation. PMFs affect the alignment of the ankle mortise and the stability of syndesmosis. Techniques described for fixation of PMFs include open reduction internal fixation through a posterolateral or posteromedial approach or anterior-to-posterior screw fixation. For selected minimally displaced or nondisplaced fractures of the posterior malleolus, we developed a percutaneous technique through the Achilles tendon for the insertion of a posterior-to-anterior cannulated screw. The technique is described, and a clinical series is reviewed.
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  • 文章类型: Case Reports
    此病例报告记录了位于下颌左下区域的实质性根尖周病变的诊断和成功治疗。患者出现临床症状,提示根尖周病理,影像学检查显示有广泛的射线可透性病变。选择的治疗方法包括牙髓干预与手术减压,导致病变的解决和口腔健康的恢复。此病例强调了准确诊断和多学科治疗方法在解决大的根尖周病变中的重要性。
    This case report documents the diagnosis and successful management of a substantial periapical lesion located in the lower left region of the jaw. The patient presented with clinical symptoms indicative of periapical pathology, and radiographic examination revealed an extensive radiolucent lesion. The chosen treatment approach involved endodontic intervention coupled with surgical decompression, leading to the resolution of the lesion and restoration of oral health. This case underscores the significance of an accurate diagnosis and a multidisciplinary treatment approach in addressing large periapical lesions.
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  • 文章类型: Journal Article
    老年人的骨折愈合与愈合能力降低有关,这通常导致延迟愈合或不愈合形成。许多因素可能导致骨再生的恶化,包括减少的血管生成创伤反应。在临床前研究中,磷酸二酯酶-3(PDE-3)抑制剂西洛他唑已显示具有促血管生成和促成骨作用。因此,我们在稳定的闭合性股骨骨折模型中分析了该化合物是否也促进老年小鼠的骨折愈合。42只年龄大的CD-1小鼠(年龄:16-18个月)每天用30mg/kg体重的西洛他唑(n=21)或媒介物(对照,n=21)通过口服管饲法。骨折后2周和5周,通过X射线分析股骨,生物力学,微型计算机断层扫描(µCT),组织学,免疫组织化学,和西方印迹。这些分析显示,2周时的弯曲刚度显着增加(2.2±0.4与4.3±0.7N/mm)和5周时骨形成增强(4.4±0.7vs.与对照相比,西洛他唑治疗的小鼠中的9.1±0.7mm3)。这与新形成的CD31阳性微血管数量增加有关(3.3±0.9vs.5.5±0.7微血管/HPF)以及磷酸肌醇-3-激酶(PI3K)的表达升高(3.6±0.8vs.17.4±5.5像素强度×104)和runt相关转录因子(RUNX)2(6.4±1.2vs.骨痂组织内18.2±2.7像素强度×104)。这些发现表明西洛他唑通过刺激血管生成和PI3K和RUNX2的表达来加速老年小鼠的骨折愈合。因此,西洛他唑可能是促进老年患者骨再生的有前途的化合物。
    Fracture healing in the aged is associated with a reduced healing capacity, which often results in delayed healing or non-union formation. Many factors may contribute to this deterioration of bone regeneration, including a reduced \'angiogenic trauma response\'. The phosphodiesterase-3 (PDE-3) inhibitor cilostazol has been shown to exert pro-angiogenic and pro-osteogenic effects in preclinical studies. Therefore, we herein analyzed in a stable closed femoral fracture model whether this compound also promotes fracture healing in aged mice. Forty-two aged CD-1 mice (age: 16-18 months) were daily treated with 30 mg/kg body weight cilostazol (n = 21) or vehicle (control, n = 21) by oral gavage. At 2 and 5 weeks after fracture, the femora were analyzed by X-ray, biomechanics, micro-computed tomography (µCT), histology, immunohistochemistry, and Western blotting. These analyses revealed a significantly increased bending stiffness at 2 weeks (2.2 ± 0.4 vs. 4.3 ± 0.7 N/mm) and an enhanced bone formation at 5 weeks (4.4 ± 0.7 vs. 9.1 ± 0.7 mm3) in cilostazol-treated mice when compared to controls. This was associated with a higher number of newly formed CD31-positive microvessels (3.3 ± 0.9 vs. 5.5 ± 0.7 microvessels/HPF) as well as an elevated expression of phosphoinositide-3-kinase (PI3K) (3.6 ± 0.8 vs. 17.4 ± 5.5-pixel intensity × 104) and runt-related transcription factor (RUNX)2 (6.4 ± 1.2 vs. 18.2 ± 2.7-pixel intensity × 104) within the callus tissue. These findings indicate that cilostazol accelerates fracture healing in aged mice by stimulating angiogenesis and the expression of PI3K and RUNX2. Hence, cilostazol may represent a promising compound to promote bone regeneration in geriatric patients.
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