■感染性心内膜炎(IE)是一种严重而致命的疾病,人工瓣膜心内膜炎代表最差的预后。推荐的核成像模式2-脱氧-2-[18F]氟-D-葡萄糖正电子发射断层扫描/计算机断层扫描([18F]FDGPET/CT)具有局限性。在这个系列中,我们介绍了用新型PET示踪剂[64Cu]Cu-DOTATATE([64Cu]Cu-[1,4,7,10-四氮杂环十二烷-N,N\',N″,N-四乙酸]-d-Phe1,Tyr3-奥曲酯)。
■一名84岁女性患者(患者1)使用生物二尖瓣假体(MVP)从门诊就诊。经食管超声心动图显示MVP上有植被。患者接受了[64Cu]Cu-DOTATATEPET/CT,这表明在感染部位摄取。患者接受了外科瓣膜置换术。术后无明显并发症,病人出院了.在另一种情况下,一名72岁男性患者(患者2),有轻度二尖瓣狭窄病史,主动脉瓣狭窄,胃肠道间质瘤因背部和腹部疼痛和低热发作而入院。经食管超声心动图显示天然主动脉瓣有大量植被。患者接受了[64Cu]Cu-DOTATATEPET/CT,这表明在疑似感染的部位没有摄取。患者接受了外科瓣膜置换术。术后以白色念珠菌胸膜炎为特征,在长期住院后,患者死于脓毒症并发症的呼吸衰竭。
■总而言之,这是第一个病例系列,介绍两名患有明确IE(修改后的Duke标准)的患者,用新型[64Cu]Cu-DOTATATEPET/CT扫描。病人1,MVP有心内膜炎,显示示踪剂的摄取,而患者2,患有天然主动脉瓣心内膜炎,没有显示任何摄取。
UNASSIGNED: Infective endocarditis (IE) is a serious and fatal condition, with prosthetic valve endocarditis representing the worst prognosis. The recommended nuclear imaging modality 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) has limitations. In this case series, we present two patients with IE scanned with a novel PET tracer [64Cu]Cu-DOTATATE ([64Cu]Cu-[1,4,7,10-tetraazacyclododecane-N,N\',N″,N‴-tetra acetic acid]-d-Phe1, Tyr3-octreotate).
UNASSIGNED: An 84-year-old female patient (Patient 1) with a biological mitral valve prosthesis (MVP) was admitted acutely from the outpatient clinic. Transoesophageal echocardiography showed vegetations on the MVP. The patient underwent [64Cu]Cu-DOTATATE PET/CT, which showed uptake at the site of infection. The patient underwent surgical valve replacement. The post-operative period was without significant complications, and the patient was discharged home. In another case, a 72-year-old male patient (Patient 2) with a medical history of mild mitral valve stenosis, aortic valve stenosis, and gastrointestinal stromal tumour was admitted to the hospital for back and abdominal pain and subfebrile episodes. Transoesophageal echocardiography showed large vegetations in the native aortic valve. The patient underwent [64Cu]Cu-DOTATATE PET/CT, which showed no uptake at the site of the suspected infection. The patient underwent surgical valve replacement. The post-operative period was characterized by Candida albicans sternitis, and after prolonged hospitalization, the patient died of respiratory failure as a complication of sepsis.
UNASSIGNED: In conclusion, this is the first case series presenting two patients with definite IE (modified Duke criteria), who were scanned with the novel [64Cu]Cu-DOTATATE PET/CT. Patient 1, with endocarditis in the MVP, showed an uptake of the tracer, while Patient 2, with native aortic valve endocarditis, did not show any uptake.