■神经纤维瘤,一种罕见的周围神经系统良性肿瘤,可以沿着神经从背神经节到其末端分支的任何地方表现出来。粘液样神经纤维瘤可以表现为孤立的非压痛结节,通常通过S-100蛋白的阳性免疫组织化学染色得到证实。然而,在50%的案例中,神经纤维瘤与神经纤维瘤病有关。
■我们介绍了一例34岁男性左大腿后部轻度疼痛的病例,伴随着一个缓慢增长的肿胀,特别明显的弯曲他的膝盖。它的大小在几个月内逐渐增加,患者观察到膝盖伸展程度降低。最初的活检显示神经鞘瘤,没有恶性肿瘤的证据。四年后,肿胀的大小增加,需要切除手术,露出一个不规则的巨大肿瘤,大小为8*6*4.5厘米,粘附于相邻结构,包括股骨,肌肉,动脉和静脉,坐骨神经的一个分支.病理分析将诊断重新分类为低度粘液样神经纤维瘤。随访3个月后MRI显示完全切除,无肿瘤残留或复发。
■孤立性神经纤维瘤通常体积较小,范围从1到2厘米的最大尺寸。或者,作为遗传性神经纤维瘤病的一部分而发生的肿瘤往往是多发性的,并且经常长成大尺寸。在我们的案例中,尽管患者有约8*6*4.5cm的巨大肿瘤,但患者没有达到神经纤维瘤病的诊断标准。据我们所知,这是除神经纤维瘤病外的大腿巨大粘液样孤立性神经纤维瘤的首次报道。因此,在对该部位肿瘤进行鉴别诊断时,应考虑这种类型的肿瘤.
UNASSIGNED: Neurofibroma, a rare benign tumor of the peripheral nervous system, can manifest anywhere along a nerve from the dorsal ganglion to its terminal branches. Myxoid
neurofibroma can present as a solitary non-tender nodule and is often confirmed by positive immunohistochemical staining for S-100 protein. However, in 50% of cases, neurofibromas are associated with neurofibromatosis.
UNASSIGNED: We present a case of a 34-year-old male with mild pain in the posterior part of his left thigh, accompanied by a slowly-growing swelling particularly noticeable when flexing his knee. It had gradually increased in size over several months, which the patient observed as a decrease in the degree of knee extension. Initial biopsy indicated schwannoma with no evidence of malignancy. Four years later, the swelling increased in size and necessitated resection surgery, revealing an irregular giant tumor measuring 8 *6 *4.5 cm, adherent to adjacent structures, including the femur, muscles, popliteal artery and vein, and a branch of the sciatic nerve. Pathological analysis reclassified the diagnosis to low-grade myxoid
neurofibroma. Follow-up MRI three months later showed gross total resection without residual or recurrence of the tumor.
UNASSIGNED: Solitary neurofibromas are often small in size, ranging from 1 to 2 cm in the greatest dimension. Alternatively, tumors that occur as a part of genetic neurofibromatosis tend to be multiple and often grow to large sizes. In our case, the patient didn\'t have neurofibromatosis as he didn\'t meet its diagnostic criteria despite having a giant tumor measuring approximately 8*6*4.5 cm. To our knowledge, this is the first report of giant myxoid solitary
neurofibroma of the thigh apart from neurofibromatosis. Thus, this type of tumor should be considered in the differential diagnosis of tumors at this location.