■窄带UVB(NBUVB)最近在越南用于治疗牛皮癣。然而,没有关于越南患者采用统一的国家协议的数据.
■本研究旨在建立治疗越南患者银屑病的最佳NBUVB疗法。
■纳入122例寻常型银屑病患者。他们被随机分为两组:百分比剂量(第1组,62例患者)和固定剂量(第2组,60例患者)。在第1组中,起始剂量为最小红斑剂量(MED)的50%,在下一个疗程中调整了10%的增量剂量。在第2组中,起始剂量基于Fitzpatrick皮肤类型(固定剂量)。采用银屑病面积和严重程度指数(PASI)评价疗效。
■超过68%的患者在第36次疗程中获得PASI75。与第1组(14.1±4.3J/cm2vs18.0±8.0J/cm2,P-值=0.0075)相比,第2组具有显著更少的疗程(20±5vs25±7,P-值=0.0004)和更低的累积剂量以实现PASI75。第2组比第1组的不良反应更常见,包括烧灼感/红斑(43.33%vs14.52%,P值=0.0009)和瘙痒(75.00%vs22.58%,P-值<0.0001)。
■NBUVB治疗对越南银屑病患者是安全有效的。固定剂量产生更快的临床反应,疗程更少,累积剂量更低。两组的不良反应均较轻,基于MED的剂量不良反应较少。对于建议,一个固定的剂量应该应用于那些对副作用不太关注的患者,而基于MED的剂量可能适用于患有与光敏相关的病症的患者。
UNASSIGNED: Narrowband UVB (
NBUVB) has recently been used in Vietnam for the treatment of psoriasis. However, there are no data on Vietnamese patients to adopt a uniform national protocol.
UNASSIGNED: This study aimed to establish an optimal
NBUVB therapy for the treatment of psoriasis in Vietnamese patients.
UNASSIGNED: One hundred and twenty-two patients with psoriasis vulgaris were included. They were randomly allocated to two groups: the percentage dose (group 1, 62 patients) and the fixed dose (group 2, 60 patients). In group 1, the starting dose was 50% of the minimal erythema dose (MED) and the 10% increment dose adjusted in the next sessions. In group 2, the starting dose was based on Fitzpatrick skin types (fixed dose). Psoriasis area and severity index (PASI) was used to evaluate efficacy.
UNASSIGNED: More than 68% of the patients get PASI75 at session 36. Group 2 had significantly fewer sessions (20 ± 5 vs 25 ± 7, P- value = 0.0004) and lower cumulative dose than group 1 (14.1 ± 4.3 J/cm2 vs 18.0 ± 8.0 J/cm2, P- value = 0.0075) to achieve PASI75. Adverse effects were more common in group 2 than group 1, including burning sensation/erythema (43.33% vs 14.52%, P- value = 0.0009) and pruritus (75.00% vs 22.58%, P- value <0.0001).
UNASSIGNED: NBUVB therapy was safe and effective for Vietnamese psoriasis patients. Fixed doses produced a quicker clinical response with fewer sessions and lower cumulative doses. Adverse effects were mild in both groups and less noted for the MED-based dose. For the recommendation, a fixed dose should be applied for patients who have less concern about side effects, while a MED-based dose can be suitable for patients having conditions related to light sensitivity.