目的:中风后的中枢打嗝是一种常见的并发症,对中风状况和患者的日常生活都产生不利影响。现有的治疗表现出有限的功效和明显的副作用。针灸已被探索作为临床实践中的辅助干预措施。本研究旨在探讨针刺治疗中风后打嗝的临床疗效。方法:确定已发表的针对中风后打嗝治疗的临床随机对照试验,在PubMed进行了全面搜索,Cochrane图书馆,EMBASE,WebofScience,中国生物医药(CBM),万方数据库,和中国科技期刊(VIP)。此外,我们仔细检查了ClinicalTrials.gov和中国临床试验注册。使用Cochrane手册5.1.0和ReviewManager5.4软件,三位作者独立回顾了文献,提取的数据,并评价研究质量。使用Stata16.0和ReviewManager5.4进行数据分析。结果:共有18项试验纳入分析。与标准治疗相比,针刺治疗效果显著提高(RR:1.27,95%CI:1.21-1.33;P<0.00001).值得注意的是,打嗝症状评分明显下降(WMD:-1.28,95%CI:-1.64至-0.93;P<0.00001),同时生活质量显著改善(WMD:8.470,95%CI:7.323-9.617;P<0.00001)。此外,不良反应发生率降低(RR:0.45,95%CI:0.16-1.25;P=0.13),SAS显著降低(WMD:-7.23,95%CI:-8.47--5.99;P<0.00001)。结论:我们的研究表明,针灸可以证明对中风后打嗝治疗有效。尽管如此,由于对纳入研究的质量和规模的担忧,开展更高质量的随机对照试验以验证其疗效势在必行.
Aim: Central hiccups following a stroke are a frequent complication, exerting adverse effects on both the stroke condition and the patient\'s daily life. Existing treatments exhibit limited efficacy and pronounced side effects. Acupuncture has been explored as a supplementary intervention in clinical practice. This study aims to investigate the clinical effectiveness of acupuncture for post-stroke hiccups.Methods: To identify published clinical randomized controlled trials addressing post-stroke hiccups treatment, comprehensive searches were conducted across PubMed, the Cochrane Library, EMBASE, Web of Science, Chinese Biological Medical (CBM), Wanfang Database, and China Science and Technology Journal (VIP). In addition, we scrutinized ClinicalTrials.gov and the Chinese Clinical Trial Registry. Employing Cochrane Handbook 5.1.0 and Review Manager 5.4 software, three authors independently reviewed literature, extracted data, and evaluated study quality. Data analysis was performed using Stata 16.0 and Review Manager 5.4.Results: A total of 18 trials were encompassed in the analysis. In comparison to standard treatment, acupuncture exhibited a significant enhancement in treatment effectiveness (RR: 1.27, 95% CI: 1.21-1.33; P < 0.00001). Notably,
Hiccup Symptom Score displayed a considerable decrease (WMD: -1.28, 95% CI: -1.64 to -0.93; P < 0.00001), concurrent with a noteworthy improvement in the quality of life (WMD: 8.470, 95% CI: 7.323-9.617; P < 0.00001). Additionally, the incidence of adverse reactions decreased (RR: 0.45, 95% CI: 0.16-1.25; P = 0.13), and there was a significant reduction in SAS (WMD: -7.23, 95% CI: -8.47 - -5.99; P < 0.00001).Conclusions: Our investigation suggests that acupuncture could prove effective in post-stroke
hiccup treatment. Nonetheless, due to concerns about the quality and size of the included studies, conducting higher-quality randomized controlled trials to validate their efficacy is imperative.