未经证实:当免疫系统被外来红细胞表面抗原致敏时,孕妇会对Rh抗原进行母体红细胞同种免疫,在这种情况下,胎儿红细胞,诱导免疫反应。血型系统的各种抗原可能导致同种免疫,尤其是Rh,凯尔,Fy,JK,MNS系统。这项研究旨在确定乌干达西南部孕妇对Rh抗原不同频率的同种免疫。
UNASSIGNED:在2020年8月至2021年7月期间,共有1369名孕妇同意并被招募参加横断面研究。获得抗凝血和凝固的血液样品(4毫升),在OrthoBiovueID-Micro分型系统中,使用LISSID-Card技术的凝集技术进行了包括Rh抗原和间接抗球蛋白试验(IAT)的Rh血型鉴定。
未经评估:在招募到该研究的1369名参与者中,78(5.7%)为D-,1291是D+,134例(9.8%)有同种抗体。在那些有同种抗体的人中,115(85.8%)为D+,19(14.2%)为D-。根据Rh抗原的同种免疫百分比在e中最高(9.72%),c(2.48%),C(2.34%)和E(0.94%)抗原。有了ABO系统,同种免疫在血型B中最高(10.7%),其次是A(10.6%),O(9.2%),然后AB(7.1%)。D-(24%)的同种异体免疫比D参与者(8.9%)更普遍。恒河猴抗原e是最普遍的抗原(99.8%),其次是c。这些参与者中9.8%的同种免疫率很高,同时出现在D+和D-女性中。其他恒河猴抗原可以引起同种免疫,抗原e引起的患病率最高。总之,有必要鉴定抗体并研究结果的临床意义,尤其是D+女性,以促进适当的妊娠管理。
UNASSIGNED: Maternal red cell alloimmunization to Rh antigen in pregnant women occurs when the immune system is sensitized by foreign red blood cell surface antigens, in this case fetal red blood cells, inducing an immune response. Various antigens of blood group systems may cause alloimmunization, especially the Rh, Kel, Fy, JK, and MNS systems. This study aimed to determine alloimmunization to the different frequencies of Rh antigen among pregnant women in South Western Uganda.
UNASSIGNED: A total of 1369 pregnant women consented and were recruited into a cross-sectional study during their regular antenatal visits during the period August 2020 to July 2021. Samples (4 mL) of anticoagulated and coagulated blood were obtained, and Rh blood grouping including Rh antigen and the indirect antiglobulin test (IAT) was carried out using the agglutination technology of the LISS ID-Card technique in the Ortho Biovue ID-Micro Typing System.
UNASSIGNED: Out of 1369 participants recruited to the study, 78 (5.7%) were D-, 1291 were D+, and 134 (9.8%) had alloantibodies. Among those with alloantibodies, 115 (85.8%) were D+ and 19 (14.2%) D-. The percentage alloimmunization according to the Rh antigens was highest in e (9.72%), c (2.48%), C (2.34%) and E (0.94%) antigens. With the ABO system, alloimmunization was highest in blood group B (10.7%), followed by A (10.6%), O (9.2%) and then AB (7.1%). Alloimmunization was more prevalent in D- (24%) than in D+ participants (8.9%). Rhesus antigen e was the most prevalent antigen (99.8%), followed by c. The alloimmunization rate of 9.8% among these participants is high, and appears in both D+ and D- women. The other Rhesus antigens are seen to cause alloimmunization, with antigen e causing the highest prevalence. In conclusion, there is a need to identify antibodies and study the outcome for clinical significance, especially in D+ women, to facilitate proper pregnancy management.