背景:这项研究在3-1000kHz频率范围内评估了人肝组织中的电导率,以比较体内与离体条件下的正常与肿瘤组织。
方法:从20例接受肝切除术的患者中获得了先前的知情同意书,这些患者在手术期间和切除术后测量了肝电导率。
结果:我们发现肿瘤组织在体内的电导率值均高于正常组织(0.41±0.10vs.0.13±0.06S/m)和离体(0.27±0.09vs.0.12±0.07S/m)条件(在3kHz时)。电特性还显示出区分包括转移在内的不同组织类型的有希望的潜力。胆管癌(CCA),肝细胞癌(HCC),肝硬化,和正常肝脏(体内和离体)。在3kHz时,胆管癌的体内电导率,HCC,转移分别为0.35、0.42±0.13和0.41±0.08S/m,分别,两者差异显著(p<0.05)。
结论:这些发现可能通过电导率测量和涉及电场的治疗技术改善肝脏疾病诊断。未来的研究应该集中在扩大样本量,以完善不同人类肝脏组织类型的分类和比较过程。
BACKGROUND: This study evaluated electrical conductivity in human liver tissue in the 3-1000 kHz frequency range to compare normal versus tumor tissues under in vivo versus ex vivo conditions.
METHODS: Previous informed consent was obtained from twenty patients undergoing liver resection in whom liver electrical conductivity was measured during surgery and after resection.
RESULTS: We found higher electrical conductivity values in tumor tissues than in normal tissue in both in vivo (0.41 ± 0.10 vs. 0.13 ± 0.06 S/m) and ex vivo (0.27 ± 0.09 vs. 0.12 ± 0.07 S/m) conditions (at 3 kHz). The electric properties also showed a promising potential for distinguishing between different tissue types including metastasis, cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatic cirrhosis, and normal liver (both in vivo and ex vivo). At 3 kHz, in vivo electrical conductivity for cholangiocarcinoma, HCC, and metastasis were 0.35, 0.42 ± 0.13, and 0.41 ± 0.08 S/m, respectively, which differed significantly from each other (p < 0.05).
CONCLUSIONS: These findings could potentially improve liver disease diagnostics through electrical conductivity measurements and treatment techniques involving electric fields. Future research should focus on expanding the sample size to refine the categorization and comparison processes across diverse human liver tissue types.