■在以前的研究中报道了侵入性产前检测的风险,例如流产,胎儿畸形,和出血。然而,很少比较侵入性试验之间的短期和长期结果。本研究旨在调查产科,围产期,以及在单胎妊娠中进行绒毛膜绒毛取样(CVS)或羊膜穿刺术后儿童的神经发育结果。
■这项回顾性队列研究包括健康的单胎妊娠,在2012年至2022年期间在单个医疗中心进行经腹CVS(孕龄[GA]10-13周)或羊膜穿刺术(GA15-21周)。只有遗传结果正常的病例才合格。评估短期和长期神经发育结果。
■该研究包括200例CVS和498例羊膜穿刺术。身体质量指数没有发现显著差异,parities,以前的早产,概念方法,和宫颈长度(CL)之前的侵入性试验组间。早产率,早产胎膜早破,早产,新生儿存活率,新生儿短期发病率,和长期神经发育迟缓相似。然而,与羊膜穿刺术组(2.4%)相比,CVS组24周前因短暂CL导致的宫颈环扎率较高(7.0%).CVS显着增加了由于短CL引起的宫颈环扎的风险(校正奇数比[aOR]=3.17,95CI[1.23-8.12],p=0.016),考虑到母亲的特点。
■在单胎妊娠中,与羊膜穿刺术相比,由于子宫颈短或宫颈扩张,进行CVS导致环扎的发生率更高。这凸显了谨慎选择CVS的重要性,以及事先告知女性相关风险的必要性。
UNASSIGNED: The risks of invasive prenatal tests are reported in previous studies such as miscarriage, fetal anomalies, and bleeding. However, few compare short-term and long-term outcomes between invasive tests. This study aims to investigate obstetric, perinatal, and children\'s neurodevelopmental outcomes following chorionic villus sampling (CVS) or amniocentesis in singleton pregnancy.
UNASSIGNED: This retrospective cohort study included healthy singleton pregnancies underwent transabdominal CVS (gestational age [GA] at 10-13 weeks) or amniocentesis (GA at 15-21 weeks) at a single medical center between 2012 and 2022. Only cases with normal genetic results were eligible. Short-term and long-term neurodevelopmental outcomes were evaluated.
UNASSIGNED: The study included 200 CVS cases and 498 amniocentesis cases. No significant differences were found in body mass index, parities, previous preterm birth, conception method, and cervical length (CL) before an invasive test between the groups. Rates of preterm labor, preterm premature rupture of the membranes, preterm birth, neonatal survival, neonatal short-term morbidities, and long-term neurodevelopmental delay were similar. However, the CVS group had a higher rate of cervical cerclage due to short CL before 24 weeks (7.0%) compared to the amniocentesis group (2.4%). CVS markedly increased the risk of cervical cerclage due to short CL (adjusted odd ratio [aOR] = 3.17, 95%CI [1.23-8.12], p = 0.016), after considering maternal characteristics.
UNASSIGNED: Performing CVS resulted in a higher incidence of cerclage due to short cervix or cervical dilatation compared to amniocentesis in singleton pregnancies. This highlights the importance of cautious selection for CVS and the necessity of informing women about the associated risks beforehand.