这项研究调查了新型中药(TCM)外用洗液与负压冲洗和他达拉非联合治疗血管性勃起功能障碍的临床效果。将87例血管性勃起功能障碍患者分为观察组和对照组。观察组给予负压冲洗联合他达拉非口服,疗程4周,对照组口服他达拉非4周。观察组包括动脉性勃起功能障碍患者21例,静脉性勃起功能障碍患者22例。治疗后,IIEF-5EHS,GAD分数,PSV,观察组EDV、RI较治疗前改善(P=0.000、0.000、0.000、L0.000/R0.000、L0.000/R0.000、L0.003/R0.000)。与对照组相比,勃起功能(IIEF-5,EHS)明显改善(P=0.008,0.002)。在观察组中,动脉性勃起功能障碍21例,静脉性勃起功能障碍22例。治疗后,动脉ED的PSV明显改善(P=L0.000/R0.000),但EDV没有显著降低(P=L0.084/R0.098)。在静脉ED患者中,PSV显著升高(P=L0.026/R0.032),EDV显著降低(P=L0.000/R0.000)。提示中药负压灌洗联合他达拉非改善阴茎动脉供血,放松平滑肌,改善了血管性勃起功能障碍患者静脉血管的闭合机制,最终改善勃起功能。
This study investigates the clinical effects of the novel Traditional Chinese Medicine (TCM) topical wash used in combination with negative pressure irrigation and tadalafil for the treatment of vascular erectile dysfunction. Eighty-seven patients with vascular erectile dysfunction were divided into an observation group and a control group. The observation group was administered negative pressure irrigation (TCM) in combination with oral tadalafil for four weeks, and the control group was administered oral tadalafil for four weeks. The observation group included 21 patients with
arterial erectile dysfunction and 22 with intravenous erectile dysfunction. After treatment, IIEF-5, EHS, GAD scores, PSV, EDV and RI in observation group were improved compared with those before treatment (P = 0.000, 0.000, 0.000, L0.000/R0.000, L0.000/R0.000, L0.003/R0.000). Erectile function (IIEF-5, EHS) was significantly improved compared with the control group (P = 0.008, 0.002). In the observation group, there were 21 cases of
arterial erectile dysfunction and 22 cases of intravenous erectile dysfunction. After treatment, PSV of
arterial ED improved significantly (P = L0.000/R0.000), but EDV did not decrease significantly (P = L0.084/R 0.098). In patients with venous ED, PSV increased (P = L0.026/R0.032) and EDV decreased significantly (P = L0.000/R0.000). These findings suggest that TCM negative pressure lavage combined with tadalafil improves the blood supply of the penile artery, relaxes smooth muscle, and improves the closing mechanism of venous vessels in patients with vascular erectile dysfunction, ultimately improving the erectile function.