目的:大多数报告的COVID-19疫苗接种后的不良事件是短暂的。然而,持续性不良事件可能以一定频率发生.本研究旨在分析患者的背景特征和趋势,重点关注COVID-19疫苗接种后的不良事件是短暂的还是持续的。
方法:在日本一家机构进行了一项回顾性研究。
方法:研究队列包括2021年5月至2023年9月期间接种COVID-19疫苗后出现症状的47名患者。根据症状持续时间将患者分为两组:短暂组,少于四周;持续组,大于或等于四周。年龄数据,性别,身体质量指数,吸烟史,潜在条件,COVID-19疫苗接种类型,剂量的数量,发病,症状,和治疗方法是回顾性收集的。
结果:中位年龄为51.0岁,74.5%为女性,40多岁的女性比例特别高。使用含二价omicron的加强疫苗(BA.1)在持续组中比在短暂组中更为普遍(p=0.0267)。短暂组的发病在第一次接种疫苗后更为常见,而持续组的发病在第二次及以后接种疫苗后更为常见(p=0.003).关于症状,持续组的疼痛频率高于短暂组(60%vs.13.6%;p=0.001)。
结论:这项研究调查了持续性症状的存在,尤其是疼痛,在COVID-19疫苗接种后。在第二次疫苗接种后经常报告持续症状。应该指出的是,这项研究并没有否定COVID-19疫苗的有效性。
OBJECTIVE: Most reported adverse events following COVID-19 vaccination have been transient. However, persistent adverse events may occur with some frequency. This study aimed to analyze patient background characteristics and trends, with a focus on whether adverse events following COVID-19 vaccination were transient or persistent.
METHODS: A retrospective study was performed at a single institution in Japan.
METHODS: The study cohort included 47 patients who presented with symptoms after COVID-19 vaccination between May 2021 and September 2023. The patients were classified into two groups based on the duration of symptoms: transient group, less than four weeks; persistent group, greater than or equal to four weeks. Data on age, sex, body mass index, smoking history, underlying conditions, type of COVID-19 vaccination, number of doses, onset, symptoms, and treatments were collected retrospectively.
RESULTS: The median age was 51.0 years and 74.5% were females, with a particularly high proportion of women in their 40s. The use of the bivalent omicron-containing booster vaccine (BA.1) was significantly more common in the persistent group than in the transient group (p = 0.0267). Onset in the transient group was more common after the first vaccination, whereas onset in the persistent group was more common after the second and subsequent vaccinations (p = 0.003). Regarding symptoms, pain was more frequent in the persistent group than in the transient group (60% vs. 13.6%; p = 0.001).
CONCLUSIONS: This study investigated the presence of persistent symptoms, especially pain, after COVID-19 vaccination. Persistent symptoms were frequently reported after the second vaccination. It should be noted that the study does not negate the usefulness of COVID-19 vaccines.