■这项研究调查了不同银屑病表现的银屑病关节炎(PsA)风险,考虑性别和种族。
■使用TriNetX,一个联邦数据库,包含超过1.2亿份电子健康记录(EHR),我们进行了全球回顾性队列研究.寻常型牛皮癣(Pso),掌plant脓疱病(PPP),使用ICD-10代码检索了广泛性脓疱型银屑病(3GPP)队列。倾向得分匹配,结合年龄,性别,和种族,被雇用。另一种倾向匹配模型还包括已建立的PsA风险因素。
■我们从486(黑人或非裔美国人分层,3GPP)到美国合作网络的35,281(Pso)EHR。出现明显的PsA风险变化:Pso具有最高风险[风险比(HR)87.7,置信区间(CI)63.4-121.1,p<0.001],其次是3GPP(HR26.8,CI6.5-110.1,p<0.0001),和购买力平价(HR15.3,CI7.9-29.5,p<0.0001)。此外,我们确定了PsA发展中性别和种族的显著差异。例如,与男性Pso患者相比,女性Pso患者的PsA风险升高(HR1.1,CI1.1-1.2,p=0.002).此外,与黑人或非裔美国人相比,白人Pso患者发生PsA的可能性更高(HR1.3,CI1.04-1.7,p=0.0244)。我们使用替代倾向匹配策略和独立数据库验证了关键发现。
■这项研究描绘了牛皮癣形式中细微的PsA风险概况,强调性别和种族的关键作用。将这些因素纳入PsA风险评估可以实现量身定制的监测和干预措施,可能影响牛皮癣患者的护理质量。
UNASSIGNED: This study investigated psoriatic arthritis (PsA) risk across varied psoriasis manifestations, considering sex and ethnicity.
UNASSIGNED: Using
TriNetX, a federated database encompassing over 120 million electronic health records (EHRs), we performed global retrospective cohort studies. Psoriasis vulgaris (Pso), pustulosis palmoplantaris (PPP), and generalized pustular psoriasis (GPP) cohorts were retrieved using ICD-10 codes. Propensity score matching, incorporating age, sex, and ethnicity, was employed. An alternative propensity matching model additionally included established PsA risk factors.
UNASSIGNED: We retrieved data from 486 (Black or African American-stratified, GPP) to 35,281 (Pso) EHRs from the US Collaborative Network. Significant PsA risk variations emerged: Pso carried the highest risk [hazard ratio (HR) 87.7, confidence interval (CI) 63.4-121.1, p < 0.001], followed by GPP (HR 26.8, CI 6.5-110.1, p < 0.0001), and PPP (HR 15.3, CI 7.9-29.5, p < 0.0001). Moreover, we identified significant sex- and ethnicity-specific disparities in PsA development. For instance, compared to male Pso patients, female Pso patients had an elevated PsA risk (HR 1.1, CI 1.1-1.2, p = 0.002). Furthermore, White Pso patients had a higher likelihood of developing PsA compared to their Black or African American counterparts (HR 1.3, CI 1.04-1.7, p = 0.0244). We validated key findings using alternative propensity matching strategies and independent databases.
UNASSIGNED: This study delineates nuanced PsA risk profiles across psoriasis forms, highlighting the pivotal roles of sex and ethnicity. Integrating these factors into PsA risk assessments enables tailored monitoring and interventions, potentially impacting psoriasis patient care quality.